老年心绞痛患者单核细胞表面补体调节蛋白与冠状动脉狭窄程度的相关性研究  

Study on the correlation between surface complement regulatory protein of monocytes and the degree of coronary artery stenosis in elderly patients with angina pectoris

作　　者：徐斌 高枫[1] 陈浩[1] 钟玲 吴禹宏 苏伟[1] XU Bin;GAO Feng;CHEN Hao;ZHONG Ling;WU Yu-hong;SU Wei(Department of Cardiology,Wuxi Hospital of Traditional Chinese Medicine,Wuxi,Jiangsu,214071,China)

机构地区：[1]无锡市中医医院心血管内科,江苏无锡214071

出　　处：《心血管康复医学杂志》2024年第2期140-144,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：2022年无锡市中医药科技项目(ZYZD01);2020年度无锡市“太湖人才计划”医疗卫生高层次人才项目。

摘　　要：目的:探讨老年心绞痛患者单核细胞表面补体调节蛋白与冠状动脉狭窄程度的相关性。方法:本研究为横断面研究。根据Gensini评分将2021年1月~6月在我院住院并行冠脉造影的老年心绞痛患者120例分为低评分组(Gensini评分≤20分,55例)和高评分组(Gensini评分>20分,65例)。比较两组患者的一般临床资料及单核细胞表面补体调节蛋白的表达。分析Gensini评分和补体调节蛋白及临床各指标的相关性。结果:与低评分组比较,高评分组低密度脂蛋白胆固醇(LDL-C)[(2.26±0.78)mmol/L比(2.63±0.73)mmol/L]水平及糖尿病史比例(21.8%比38.5%)显著升高,而单核细胞表面CD35[9.86(8.33,12.51)比6.44(4.26,8.16)]、CD46[13.28(11.42,14.66)比10.42(9.19,15.38)]、CD55[39.90(32.40,47.48)比22.66(19.18,26.97)]表达显著降低(P<0.05或<0.01)。Spearman相关分析结果显示,高评分组Gensini评分与LDL-C呈显著正相关(r=0.292,P=0.018),与单核细胞表面CD35、CD46、CD55表达呈显著负相关(r=-0.870,P<0.001;r=-0.327,P<0.001;r=-0.200,P=0.028)。多因素Logistic回归分析结果显示LDL-C是老年心绞痛患者高Gensini评分的独立危险因素(OR=2.517,P=0.036),而CD35、CD55为其独立保护因素(OR=0.786、0.670,P<0.05或<0.01)。结论:老年心绞痛合并冠脉严重狭窄患者单核细胞表面CD35、CD46和CD55表达与冠脉狭窄程度呈显著负相关。Objective:To explore the correlation between surface complement regulatory proteins of monocytes and the degree of coronary artery stenosis in elderly patients with angina pectoris.Methods:This was a cross-sectional study.A total of 120 elderly patients with angina pectoris who admitted in our hospital from Jan 2021 to Jun 2021 and underwent coronary angiography were divided into low score group(Gensini score≤20 points,n=55)and high score group(Gensini score>20 points,n=65)according to the Gensini score.General clinical data and the expressions of monocyte surface complement regulatory proteins were compared between the two groups.The correlation among complement regulatory proteins,clinical indexes and Gensini score were analyzed.Results:Compared with low score group,there were significant rise in level of low density lipoprotein cholesterol(LDL-C)[(2.26±0.78)mmol/L vs.(2.63±0.73)mmol/L]and proportion of diabetes history(21.8%vs.38.5%),and significant reductions in expressions of monocyte surface CD35[9.86(8.33,12.51)vs.6.44(4.26,8.16)],CD46[13.28(11.42,14.66)vs.10.42(9.19,15.38)]and CD55[39.90(32.40,47.48)vs.22.66(19.18,26.97)]in high score group,P<0.05 or<0.01.Spearman correlation analysis indicated that in high score group,Gensini score was significant positively correlated with LDL-C level(r=0.292,P=0.018),and significant inversely correlated with expressions of monocyte surface CD35,CD46 and CD55(r=-0.870,P<0.001;r=-0.327,P<0.001;r=-0.200,P=0.028).Multivariate Logistic regression indicated that LDL-C was independent risk factor for high Gensini score in elderly patients with angina pectoris(OR=2.517,P=0.036),while CD35 and CD55 were its independent protective factors(OR=0.786、0.670,P<0.05 or<0.01).Conclusion:The expressions of monocyte surface CD35,CD46 and CD55 are significant inversely correlated with the degree of coronary artery stenosis in elderly patients with angina pectoris and severe coronary stenosis.

关 键 词：心绞痛 补体调节蛋白 冠状动脉狭窄 

分 类 号：R541.409[医药卫生—心血管疾病]