极化液联合小剂量多巴胺治疗射血分数降低心力衰竭疗效观察  

Therapeutic effect of GIK combined with low-dose dopamine on heart failure with reduced ejection fraction

作　　者：郑禹樵 刘丽[1] 马丽娜[2] 贾红丹[1] 宋婷婷[1] 于琪力 李林桐 石琳 张邵杰 陈金良 ZHENG Yu-qiao;LIU Li;MA Li-na;JIA Hong-dan;SONG Ting-ting;YU Qi-li;LI Lin-tong;SHI Lin;ZHANG Shao-jie;CHEN Jin-liang(Department of Cardiology,First Hospital of Qinhuangdao City,Qinhuangdao,Hebei,066000,China)

机构地区：[1]秦皇岛市第一医院心内科,河北秦皇岛066000 [2]秦皇岛市第一医院神经内科,河北秦皇岛066000 [3]解放军北戴河康复疗养中心心内科

出　　处：《心血管康复医学杂志》2024年第2期202-206,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨极化液联合小剂量多巴胺对射血分数减低型心力衰竭(HFrEF)的临床疗效。方法:选择2022年1月至6月我院收治的HFrEF患者124例,随机分为对照组(60例,抗心力衰竭基础治疗)和治疗组(64例,在常规治疗基础上加用极化液联合小剂量多巴胺静脉滴注),疗程5d。对比两组治疗前后血N末端脑钠肽前体(NT-proBNP)、血肌酐(SCr)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDd)的变化,并记录观察两组治疗期间不良反应情况。结果:与对照组治疗后比较,治疗组NT-proBNP[(3690.68±1091.98)pg/ml比(2798.38±1112.07)pg/ml]、SCr[(93.23±7.02)μmol/L比(77.90±6.75)μmol/L]、LVEDd[(54.57±2.06)mm比(53.83±1.80)mm]均显著降低,LVEF[(40.50±3.41)%比(41.89±3.39)%]显著升高(P<0.05或<0.01)。治疗组总不良反应发生率显著低于对照组(28.1%比55.0%,P=0.002)。结论:常规治疗基础上加用极化液联合小剂量多巴胺,可以显著提高射血分数减低型心力衰竭患者的左室射血分数,缩小左室舒张末内径,保护肾脏功能,且不良反应发生率较低。Objective:To explore clinical effect of glucose-insulin-potassium(GIK)combined with low-dose dopamine on heart failure with reduced ejection fraction(HFrEF).Methods:A total of 124 HFrEF patients treated in our hospital from Jan to Jun,2022 were enrolled,randomly divided into control group(n=60,basic therapy for heart failure)and treatment group(n=64,received GIK combined with low-dose dopamine intravenous drip based on routine treatment),both groups were treated for 5d.Levels of N terminal pro brain natriuretic peptide(NT-proBNP),serum creatinine(SCr),left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDd)before and after treatment,and incidence of adverse reactions during treatment were observed and compared between two groups.Results:Compared with control group after treatment,there were significant reductions in levels of NT-proBNP[(3690.68±1091.98)pg/ml vs.(2798.38±1112.07)pg/ml],SCr[(93.23±7.02)μmol/L vs.(77.90±6.75)μmol/L]and LVEDd[(54.57±2.06)mm vs.(53.83±1.80)mm],and significant rise in LVEF[(40.50±3.41)%vs.(41.89±3.39)%]in treatment group,P<0.05 or<0.01.The total incidence rate of adverse reactions in treatment group was significantly lower than that of control group(28.1%vs.55.0%,P=0.002).Conclusion:GIK combined with low-dose dopamine based on routine treatment can significantly improve left ventricular ejection fraction,reduce left ventricular end-diastolic diameter and protect kidney function in patients with heart failure with reduced ejection fraction,and the incidence rate of adverse reactions is low.

关 键 词：心力衰竭 极化液 多巴胺 

分 类 号：R541.6[医药卫生—心血管疾病]