6min步行距离联合NT-proBNP对射血分数保留型心力衰竭的诊断价值  

Diagnostic value of 6 min walking distance combined with NT-proBNP for heart failure with preserved ejection fraction

作　　者：董毓辉[1] 王冰[1] DONG Yu-hui;WANG Bing(Heart Failure Center,First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心衰中心,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2024年第2期206-210,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨6min步行距离(6MWD)和N末端脑钠肽前体(NT-proBNP)对射血分数保留型心力衰竭(HFpEF)的诊断价值。方法:回顾性分析2019年1月至2021年4月哈尔滨医科大学附属第一医院心内科收治的80例HFpEF患者(HFpEF组)和同期体检的85例健康对照者(健康对照组)的临床资料。比较两组一般资料、6MWD和血浆NT-proBNP的水平,利用受试者工作特征曲线(ROC)评估6MWD和血浆NT-proBNP及二者联合检测对HFpEF的诊断价值。结果:与健康对照组比较,HFpEF组血浆NT-proBNP水平[436.31(410.93,476.40)pg/ml比960.25(750.40,1460.50)pg/ml]显著升高,6MWD[440.00(412.00,460.00)m比359.00(300.00,403.75)m]显著降低,P均=0.001。ROC曲线分析显示,血浆NT-proBNP和6MWD都对HFpEF具有较高诊断价值(曲线下面积(AUC)=0.935、0.821),其截断值分别为511.9pg/ml和385.0m,且联合检测的AUC(0.943)高于单一检测,提示联合检测具有更高的诊断价值。结论:6min步行距离联合血浆N末端脑钠肽前体检测对HFpEF具有较高的诊断价值。Objective:To investigate the diagnostic value of 6 min walking distance(6MWD)and N-terminal pro-brain natriuretic peptide(NT-proBNP)for heart failure with preserved ejection fraction(HFpEF).Methods:Clinical data of 80 HFpEF patients(HFpEF group)who admitted to Department of Cardiology,First Affiliated Hospital of Harbin Medical University from January 2019 to April 2021,and 85 healthy subjects(healthy control group)who simultaneously received physical examination were retrospectively analyzed.General data,6MWD and plasma NT-proBNP level were compared between two groups,and the receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of 6MWD,plasma NT-proBNP and their combined detection for HFpEF.Results:Compared with healthy control group,there was significant rise in plasma NT-proBNP level[436.31(410.93,476.40)pg/ml vs.960.25(750.40,1460.50)pg/ml],and significant reduction in 6MWD[440.00(412.00,460.00)m vs.359.00(300.00,403.75)m]in HFpEF group,P=0.001 both.ROC curve analysis indicated that both plasma NT-proBNP and 6MWD possessed high diagnostic value for HFpEF(area under the curve(AUC)=0.935,0.821),and their cut-off values were 511.9pg/ml and 385.0m respectively,and AUC of combined detection(0.943)was higher than any single test,suggesting combined detection had higher diagnostic value.Conclusion:6min walking distance combined with plasma NT-proBNP detection possess high diagnostic value for HFpEF.

关 键 词：心力衰竭 利钠肽 脑 诊断 

分 类 号：R541.6[医药卫生—心血管疾病]