心肌纤维化在左心室舒张功能不全中的作用及其作为治疗靶点的潜力  

Role of myocardial fibrosis in left ventricular diastolic dysfunction and its potential as a therapeutic target

作　　者：缪丽珠 高一群 张树龙[1] MIAO Li-zhu;GAO Yi-qun;ZHANG Shu-long(Heart Center,Affiliated Zhongshan Hospital of Dalian University,Dalian,Liaoning,116001,China)

机构地区：[1]大连大学附属中山医院心脏中心,辽宁大连116001

出　　处：《心血管康复医学杂志》2024年第2期248-252,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：心肌纤维化(Myocardial fibrosis,MF)是由缺血、缺氧等因素导致的心肌结构和功能改变,是多种心脏疾病进展过程中的重要病理变化。左心室舒张功能不全(Left ventricular diastolic dysfunction,LVDD)是多种复杂病理变化过程的综合结果,最终进展为射血分数保留型心力衰竭(HFpEF),严重影响患者生活质量及寿命。本文就MF在LVDD过程中的作用作一综述,并讨论目前的治疗研究进展。Myocardial fibrosis(MF)is an important pathological change in the progression of a variety of heart diseases due to myocardial structural and functional changes caused by factors such as ischemia and hypoxia.Left ventricular diastolic dysfunction(LVDD)is a comprehensive result of a variety of complex pathological processes,which eventually progresses to heart failure with preserved ejection fraction(HFpEF),seriously affecting the quality of life and lifetime of patients.This article reviews the role of MF in the process of LVDD,and discusses the current research progress of treatment.

关 键 词：心内膜心肌纤维化症 心室功能障碍 左 治疗 

分 类 号：R542.23[医药卫生—心血管疾病]