基于隐结构模型结合关联规则研究冠心病稳定型心绞痛中医证候特征  

TCM Symptom Characteristics of Stable Angina Pectoris in Coronary Heart Disease Based on Hidden Structure Model Combined with Association Rule

作　　者：王雪[1] 张明雪[2] WANG Xue;ZHANG Mingxue(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;Affiliated Hospital of Liaoning University of Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2024年第4期1-6,I0001,共7页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2017YFC1700400,2017YFC1700401);国家自然科学基金面上项目(81273698);辽宁省特聘教授滚动支持项目(辽教函〔2018〕35号)。

摘　　要：目的探讨冠心病稳定型心绞痛中医证候的分布及特征,为今后冠心病稳定型心绞痛的辨证论治提供客观可靠的依据。方法计算机检索中国期刊全文数据库(CNKI)、万方(WanFang)、维普(VIP)等数据库内自建库以来至2022年1月的名老中医治疗冠心病稳定型心绞痛的医案及临床经验,采用孔明灯Lantern5.0软件,应用爬山法(LTM-EAST)算法建立症状隐结构模型并进行综合聚类分析;采用SPSS Modeler 15.1软件,用Apriori算法,对中医证素进行关联规则分析并绘制复杂网络图。结果①纳入的206例医案共涉及24个中医证候,其中频次较高(>5%)的分别为心血瘀阻证、痰瘀互结证、气滞血瘀证、痰湿阻滞证、气虚血瘀证、心阳虚证、气阴两虚证。②将共计121个症状作为显变量,应用LTM-EAST算法构建结构模型,得出30个隐变量,对得出的30个隐变量进行综合聚类,共得出9个综合聚类模型即9个中医证候,分别为气滞血瘀证、心血瘀阻证、气虚血瘀证、心阳虚证、气阴两虚证、痰瘀互结证、痰湿内阻证、痰热内闭证、心肾阳虚证。③对24个中医证候提取的17个证素进行关联规则分析,推导出7个中医证候,分别为心血瘀阻证、心阳虚衰证、痰瘀互结证、气阴两虚证、阳虚血瘀证、气虚血瘀证、气滞血瘀证。结论综合归纳,最终得出6个中医常见证候,分别为:气滞血瘀证、心血瘀阻证、气虚血瘀证、心阳虚证、气阴两虚证、痰瘀互结证。Objective This paper discussed the distribution and characteristics of traditional Chinese medicine symptoms of stable angina with coronary heart disease,and provided an objective and reliable basis for the dialectical treatment of stable angina with coronary heart disease in the future.Methods The medical cases and clinical experience of famous old traditional Chinese medicine practitioners in the treatment of stable angina with coronary heart disease from the establishment of the database from CNKI,WanFang,VIP and other databases were retrieved by computer,and the hidden structure model of symptoms was established and comprehensive clustering analysis was carried out by using The Lantern5.0 software of Kong Ming Lantern,and the implicit structure model of symptoms was established and comprehensive clustering analysis was carried out by using the climbing method(LTM-EAST)algorithm Modeler 15.1 software.The Apriori algorithm was used to analyze the correlation rules of TCM syndrome and plotted complex network diagrams.Results①A total of 24 TCM syndromes were involved in the 206 medical cases included,of which the more frequent(>5%)were blood stasis in heart syndrome,syndrome of intermingled phlegm and blood stasis,Qi stagnation and blood stasis syndrome,phlegm-dampness obstruction syndrome,Qi deficiency and blood stasis syndrome,heart-Yang deficiency syndrome and Qi-Yin deficiency syndrome.②A total of 121 symptoms were used as explicit variables,the LTM-EAST algorithm was used to construct a structural model,30 hidden variables were obtained,and the 30 hidden variables were comprehensively clustered,and a total of 9 comprehensive clustering models were obtained,that is,9 traditional Chinese medicine syndromes,namely Qi stagnation and blood stasis syndrome,blood stasis in heart syndrome,Qi and Yang deficiency syndrome,deficiency of Qi and Yin syndrome,syndrome of intermingled phlegm and blood stasis,phlegm-dampness internal obstruction syndrome,syndrome of phlegm-heat blocking internally and heart and kidney Y

关 键 词：隐结构模型 关联规则 冠心病稳定型心绞痛 中医证候 

分 类 号：R256.2[医药卫生—中医内科学]