银杏二萜内酯葡胺辅助治疗对急性脑梗死患者NIHSS、ADL评分的影响  

Effects of Adjuvant Treatment with Ginkgo Diterpene Lactone Meglumine on NIHSS and ADL Scores in Patients with Acute Cerebral Infarction

作　　者：周灿富 杨保生[1] 区志明[1] 梁军[1] ZHOU Canfu;YANG Baosheng;QU Zhiming;LIANG Jun(Department of Emergency,Zhaoqing First People's Hospital,Zhaoqing 526040,Guangdong,China)

机构地区：[1]肇庆市第一人民医院急诊科,广东肇庆526040

出　　处：《辽宁中医杂志》2024年第4期122-124,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省中医药管理局建设中医药强省科研基金资助项目(20121003)。

摘　　要：目的分析银杏二萜内酯葡胺注射液辅助阿托伐他汀对急性脑梗死患者的治疗效果。方法选取2019年2月—2020年11月医院收治的100例急性脑梗死患者为研究对象,采用随机数字表法分为观察组合对照组,每组50例。在常规治疗基础上,对照组基于阿托伐他汀治疗;观察组在对照组基础联合银杏二萜内酯葡胺注射,持续2周。比较两组治疗效果、神经缺损(NIHSS)评分、日常生活能力(ADL)、白介素(IL)-6、D二聚体表达以及不良反应。结果观察组治疗总有效率96.0%高于对照组的76.0%,差异有统计学意义(P<0.05);观察组治疗后NIHSS评分(5.31±0.48)分低于对照组(7.96±0.57)分,ADL评分(76.52±8.46)分高于对照组(65.89±8.17)分,差异有统计学意义(P<0.05);观察组治疗后IL-6(6.51±1.46)ng/L、D-D(2.51±0.31)mg/L低于对照组IL-6(8.36±1.51)ng/L、D-D(3.96±0.42)mg/L,差异有统计学意义(P<0.05)。结论银杏二萜内酯葡胺联合阿托伐他汀治疗急性脑梗死,神经缺损减轻,日常生活能力提高,值得应用。Objective To analyze the curative effect of adjuvant treatment with Ginkgo diterpene lactone meglumine on patients with acute cerebral infarction(ACI).Methods A total of 100 patients with ACI admitted to the hospital were enrolled as the research objects between February 2019 and November 2020.They were divided into observation group and control group by random number table method,50 cases in each group.On the basis of routine treatment,the control group was treated with atorvastatin,while the observation group was treated with Ginkgo diterpene lactone meglumine injection on the basis of control group for 2 weeks.The curative effect,scores of National Institutes of Health Stroke Scale(NIHSS)and the activity of daily living scale(ADL),the levels of interleukin(IL)-6 and D-dimer and adverse reactions were compared between the two groups.Results The total response rate of treatment in the observation group was higher than that in the control group(96.0%vs 76.0%)(P<0.05).After treatment,the NIHSS score in the observation group was lower than that in the control group[(5.31±0.48)points vs(7.96±0.57)points],while the ADL score was higher than that in the control group[(76.52±8.46)points vs(65.89±8.17)points](P<0.05).After treatment,the levels of IL-6 and D-D in the observation group were(6.51±1.46)ng/L and(2.51±0.31)mg/L,lower than those in the control group[(8.36±1.51)ng/L,(3.96±0.42)mg/L](P<0.05).Conclusion Ginkgo diterpene lactone meglumine combined with atorvastatin can reduce the nerve defects and improve the activities of daily living in ACI.

关 键 词：银杏二萜内酯葡胺 阿托伐他汀 急性脑梗死 日常生活能力 炎症反应 

分 类 号：R255.2[医药卫生—中医内科学]