脯氨酸丹参素冰片酯对小鼠中枢神经系统的一般药理学研究  

Study on general pharmacology of proline danshensu borneol ester on the central nervous system of mice

作　　者：秦蓓[1,2,3] 王荣[1,2,3] 余丽丽[1,2,3] 张怡心[1] 谭雄 王娜娜 Qin Bei;Wang Rong;Yu Lili;Zhang Yixin;Tan Xiong;Wang Nana(Xi’an Key Laboratory of Multisynergistic Antihypertensive Innovative Drug Development,Xi’an Medical University,Xi’an 710021,Shanxi,China;Institute of Drug Research,Xi’an Medical University,Xi’an 710021,Shanxi,China;College of Pharmacy,Xi’an Medical University,Xi’an 710021,Shanxi,China)

机构地区：[1]西安医学院西安市多靶协同抗高血压创新药物研制重点实验室,陕西西安710021 [2]西安医学院药物研究所,陕西西安710021 [3]西安医学院药学院,陕西西安710021

出　　处：《贵州医药》2024年第4期524-526,531,共4页Guizhou Medical Journal

基　　金：陕西省重点研发计划项目(2021ZDLSF03-05);陕西省科技厅自然科学基础研究计划项目(2022JM-492);陕西省高校青年创新团队建设项目(陕教函[2022]943号);西安医学院校级科技创新团队(2021TD03、07);教育部产学合作协同育人项目(202101021043,220605634241456)。

摘　　要：目的 考察脯氨酸丹参素冰片酯对小鼠中枢神经系统的影响。方法 将小鼠随机分为对照组和脯氨酸丹参素冰片酯大剂量(120 mg/kg)、中剂量(60 mg/kg)、小剂量(30 mg/kg)给药组,每组10只,雌雄各半,灌胃给药后考察对小鼠自主活动、协同睡眠、协调运动能力和镇痛的作用。结果 与对照组相比,脯氨酸丹参素冰片酯对小鼠自主活、协同睡眠、协调运动能力和镇痛方面无显著影响。结论 脯氨酸丹参素冰片酯对小鼠中枢神经系统无明显影响,在药效有效剂量范围内安全性较好。Objective To explore the effects of proline danshensu borneol ester on the central nervous system of mice.Methods Mice were randomly divided into control,proline danshensu borneol ester 120 mg/kg,60 mg/kg and 30 mg/kg group,each group including 10 mice which were half male and half female.The changes in spontaneous activity,synergistic sleep,coordinated movement and analgesic effect in mice were observed.Results Compared with control group,proline danshensu borneol ester there were no effect on mice's spontaneous activity,synergistic sleep,coordinated movement and analgesic effect.Conclusion Proline danshensu borneol ester there was no significant effects on the central nervous system of mice,revealing high safety during the range of pharmacodynamic effective dose.

关 键 词：脯氨酸丹参素冰片酯 一般药理学 中枢神经系统 小鼠 

分 类 号：R969[医药卫生—药理学]