水凝胶表面增强拉曼散射基底的研究进展  

Progress of hydrogel surface-enhanced Raman scattering substrate

作　　者：宋阳阳 司承运 杜迎翔[1] 骆雪芳[1] SONG Yangyang;SI Chengyun;DU Yingxiang;LUO Xuefang(Key Laboratory of Drug Quality Control and Pharmacovigilance(Ministry of Education),China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]药物质量与安全预警教育部重点实验室/中国药科大学,江苏南京210009

出　　处：《广东药科大学学报》2024年第2期150-159,共10页Journal of Guangdong Pharmaceutical University

摘　　要：水凝胶作为表面增强拉曼散射(SERS)基底具有检测灵敏度高、均匀性好、重现性好、长期稳定、抗干扰性强、操作便捷等优势;与其他柔性SERS基底相比,水凝胶的分子筛作用可避免复杂样品中的大分子干扰,简化甚至无需样品前处理过程。本文综述了水凝胶SERS基底的研究进展,重点介绍了水凝胶SERS基底的几种常见制备方法,包括原位合成法、包埋/嵌入法、沉积法、吸附法等,以及水凝胶SERS基底在环境监测、食品安全和生物医学等方面的应用现状,为SERS技术的发展和应用提供参考。The surface-enhanced Raman scattering(SERS)composite hydrogel substrate has the advantages of high detection sensitivity,better uniformity,good reproducibility,long-term stability,strong anti-interference and ease of operation,etc.Compared with other flexible SERS substrates,the molecular sieving effect of hydrogel can preclude macromolecular interference in complex samples and simplify or even eliminate the sample pretreatment process.This review summarized the research progress of hydrogel SERS substrates,focusing on diversified strategies for fabrication of hydrogel SERS substrates,including in situ synthesis,embedding/insertion,deposition and adsorption,as well as the application status of hydrogel SERS substrates in environmental monitoring,food safety and biomedicine,which could provide references for the development and application of SERS technology.

关 键 词：表面增强拉曼散射 水凝胶基底 制备方法 应用 

分 类 号：O657.37[理学—分析化学]