不同血浆白蛋白水平肾病综合征患者的凝血状态研究  

Study on coagulation status in patients with nephrotic syndrome with different plasma albumin levels

作　　者：郑晓庆 杨立宏[1] 王彩虹[1] ZHENG Xiao-qing;YANG Li-hong;WANG Cai-hong(Department of Nephrology,Chifeng Hospital of Inner Mongolia Autonomous Region,Chifeng 024000,China)

机构地区：[1]内蒙古自治区赤峰市医院肾内科,024000

出　　处：《中国实用医药》2024年第6期77-80,共4页China Practical Medicine

摘　　要：目的 研究不同血浆白蛋白(ALB)水平肾病综合征患者的凝血状态。方法 回顾性选取60例肾病综合征患者,依据血浆白蛋白水平不同分为白蛋白25~30 g/L组、白蛋白20~25 g/L组、白蛋白<20 g/L组、正常对照组,各15例。检测四组患者的凝血指标[D-二聚体(D-D)、纤维蛋白原(Fg)、降钙素原(PCT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、血小板计数(PLT)、血小板体积分布宽度(PDW)、平均血小板体积(MPV)]。统计比较四组凝血指标,并进行白蛋白与D-D、Fg的相关性分析。结果 白蛋白25~30 g/L组D-D、Fg、PCT、APTT、PT、TT、PLT、PDW、MPV分别为(0.64±0.14)μg/ml、(5.32±1.13)g/L、(0.24±0.07)ng/ml、(36.25±0.67)s、(12.77±0.43)s、(17.58±1.18)s、(230.23±10.14)×109/L、(12.32±0.45)fl、(10.52±0.22)fl;白蛋白20~25 g/L组分别为(0.65±0.14)μg/ml、(5.35±1.25)g/L、(0.25±0.06)ng/ml、(36.64±0.72)s、(12.95±0.34)s、(17.66±1.22)s、(231.22±13.56)×109/L、(12.02±0.42)fl、(10.45±0.12)fl;白蛋白<20 g/L组分别为(1.14±0.03)μg/ml、(6.80±1.53)g/L、(0.27±0.11)ng/ml、(37.26±0.83)s、(13.20±0.30)s、(18.78±1.70)s、(272.23±11.23)×109/L、(11.62±0.45)fl、(10.25±0.14)fl;正常对照组分别为(0.14±0.04)μg/ml、(2.83±0.48)g/L、(0.20±0.10)ng/ml、(34.78±2.55)s、(12.01±0.58)s、(16.60±0.80)s、(221.23±12.05)×109/L、(12.65±0.41)fl、(11.14±0.52)fl。白蛋白<20 g/L组、白蛋白20~25 g/L组、白蛋白25~30 g/L组患者的血浆D-D、Fg、APTT、PT、TT、PLT均逐渐降低,且均高于正常对照组,白蛋白20~25 g/L组、白蛋白25~30 g/L组患者的血浆D-D、Fg、APTT、PT、TT、PLT均低于白蛋白<20 g/L组(P<0.05);白蛋白<20 g/L组、白蛋白20~25 g/L组、白蛋白25~30 g/L组患者的PDW、MPV均逐渐升高,且均低于正常对照组,白蛋白20~25 g/L组、白蛋白25~30 g/L组患者的PDW、MPV均高于白蛋白<20 g/L组(P<0.05);但白蛋白20~25 g/L组和白蛋白25~30 g/L组患者的血浆D-D、Objective To study the coagulation status in patients with nephrotic syndrome with different plasma albumin(ALB)levels.Methods 60 patients with nephrotic syndrome were retrospectively selected and divided into 25-30 g/L albumin group,20-25 g/L albumin group,albumin<20 g/L group and normal control group according to different plasma albumin levels,with 15 cases in each group.The coagulation indices[D-dimer(D-D),fibrinogen(Fg),procalcitonin(PCT),activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),platelet count(PLT),platelet distribution width(PDW),and mean platelet volume(MPV)]were detected in the four groups.The coagulation indices of the four groups were statistically compared,and the correlation of albumin with D-D and Fg was analyzed.Results In albumin 25-30 g/L group,D-D,Fg,PCT,APTT,PT,TT,PLT,PDW and MPV were(0.64±0.14)μg/ml,(5.32±1.13)g/L,(0.24±0.07)ng/ml,(36.25±0.67)s,(12.77±0.43)s,(17.58±1.18)s,(230.23±10.14)×109/L,(12.32±0.45)fl and(10.52±0.22)fl;in albumin 20-25 g/L group,they were(0.65±0.14)μg/ml,(5.35±1.25)g/L,(0.25±0.06)ng/ml,(36.64±0.72)s,(12.95±0.34)s,(17.66±1.22)s,(231.22±13.56)×109/L,(12.02±0.42)fl and(10.45±0.12)fl;in albumin<20 g/L group,they were(1.14±0.03)μg/ml,(6.80±1.53)g/L,(0.27±0.11)ng/ml,(37.26±0.83)s,(13.20±0.30)s,(18.78±1.70)s,(272.23±11.23)×109/L,(11.62±0.45)fl and(10.25±0.14)fl;in normal control group,they were(0.14±0.04)μg/ml,(2.83±0.48)g/L,(0.20±0.10)ng/ml,(34.78±2.55)s,(12.01±0.58)s,(16.60±0.80)s,(221.23±12.05)×109/L,(12.65±0.41)fl and(11.14±0.52)fl.The plasma D-D,Fg,APTT,PT,TT and PLT of albumin<20 g/L group,albumin 20-25 g/L group and albumin 25-30 g/L group were decreased gradually,and were higher than that of normal control group;the plasma D-D,Fg,APTT,PT,TT and PLT of albumin 20-25 g/L group and albumin 25-30 g/L group were lower than those of albumin<20 g/L group(P<0.05).The PDW and MPV of albumin<20 g/L group,albumin 20-25 g/L group and albumin 25-30 g/L group were all increased gradually,and were low

关 键 词：肾病综合征 血浆白蛋白 凝血状态 相关性 

分 类 号：R692[医药卫生—泌尿科学]