米非司酮联合乳酸依沙吖啶注射液羊膜腔内注射在瘢痕子宫中期妊娠引产中的应用效果  

Effect of mifepristone combined with intraamniotic injection of ethacridine lactate in termination of second trimester pregnancy in a scarred uterus

作　　者：孔冬梅 KONG Dong-mei(Qufu Maternal and Child Health and Family Planning Service Center,Jining 273100,China)

机构地区：[1]曲阜市妇幼保健计划生育服务中心,273100

出　　处：《中国实用医药》2024年第6期116-119,共4页China Practical Medicine

摘　　要：目的 探讨米非司酮联合乳酸依沙吖啶注射液羊膜腔内注射在瘢痕子宫中期妊娠引产中的效果。方法 80例瘢痕子宫中期妊娠引产患者,以数表随机方式分为对照组及观察组,每组40例。对照组应用乳酸依沙吖啶注射液羊膜腔内注射治疗,观察组应用乳酸依沙吖啶注射液羊膜腔内注射联合米非司酮口服治疗。比较两组患者引产成功率,宫缩启动时间、胎盘分娩时间以及阴道失血量,药物不良反应发生情况,引产并发症发生情况。结果 观察组引产成功率较对照组高,差异存在统计学意义(95.00%VS 77.50%,χ^(2)=5.1647, P<0.05)。观察组宫缩启动时间、胎盘分娩时间分别为(28.35±1.69)、(8.89±1.57)min,较对照组(32.67±2.58)、(11.63±2.25)min更短,阴道失血量(121.58±13.04)ml较对照组(149.63±16.59)ml更少,差异存在统计学意义(t=8.8586、6.3162、8.4072, P<0.05)。观察组药物不良反应发生率与对照组对比,无统计学差异(22.50%VS 15.00%,χ^(2)=0.7385, P>0.05)。观察组患者引产并发症发生率明显较对照组低,差异存在统计学意义(22.50%VS 55.00%,χ^(2)=8.9006, P<0.05)。结论 米非司酮联合乳酸依沙吖啶注射液羊膜腔内注射治疗瘢痕子宫中期妊娠引产的效果理想,可有效提升患者的引产成功率,并缩短产程时间,减少阴道失血量,降低并发症发生风险,同时还不会明显增加患者的药物不良反应,值得推广。Objective To explore the effect of mifepristone combined with intraamniotic injection of ethacridine lactate in termination of second trimester pregnancy in a scarred uterus.Methods 80 scarred uterus patients requiring termination of second trimester pregnancy were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with intraamniotic injection of ethacridine lactate,and the observation group was treated with intraamniotic injection of ethacridine lactate combined with oral mifepristone.The success rate of labor induction,time of uterine contraction initiation,placental delivery time,vaginal blood loss,occurrence of adverse drug reactions and complications of labor induction were compared between the two groups.Results The success rate of labor induction in the observation group was higher than that in the control group,and the difference was statistically significant(95.00%VS 77.50%,χ^(2)=5.1647,P<0.05).The time of uterine contraction initiation and placental delivery time in the observation group were(28.35±1.69)and(8.89±1.57)min,which were shorter than(32.67±2.58)and(11.63±2.25)min in the control group;the observation group had less vaginal blood loss of(121.58±13.04)ml than(149.63±16.59)ml in the control group;and the difference was statistically significant(t=8.8586,6.3162,8.4072;P<0.05).There was no significant difference in the incidence of adverse drug reactions between the observation group and the control group(22.50%VS 15.00%,χ^(2)=0.7385,P>0.05).The complication rate of labor induction in the observation group was significantly lower than that in the control group,and the difference was statistically significant(22.50%VS 55.00%,χ^(2)=8.9006,P<0.05).Conclusion Mifepristone combined with intraamniotic injection of ethacridine lactate injection has an ideal effect in termination of second trimester pregnancy in a scarred uterus,which can effectively improve the success rate of labor induction of patients,shorten the duration of

关 键 词：瘢痕子宫 中期妊娠 引产 米非司酮 乳酸依沙吖啶注射液 羊膜腔内注射 

分 类 号：R719.3[医药卫生—妇产科学]