Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians  

作　　者：Long Feng Hongqi Huo Qun Li Tao Yang Yali Zhao Pei Zhang Ping Ping Shihui Fu 

机构地区：[1]Department of Anesthesiology,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [2]Nuclear Medicine Department,Handan Central Hospital,Handan,Hebei056001,China [3]Department of Neurosurgery,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [4]Department of Oncology,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [5]Central Laboratory,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [6]School of Life Science,Beijing Institute of Technology,Beijing 100081,China [7]General Station for Drug and Instrument Supervision and Control,Joint Logistic Support Force of Chinese People's LiberationArmy,Beijing 100071,China [8]Department of Cardiology,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [9]Department of Geriatric Cardiology,Chinese People's Liberation Army General Hospital,Beijing 100853,China

出　　处：《Genes & Diseases》2024年第3期106-108,共3页基因与疾病（英文）

基　　金：supported by grants from the Military Medical Science and Technology Youth Incubation Program(No.20QNPY110,19QNP060);the National Natural Science Foundation of China(No.81900357,81941021,81903392,81901252,82001476,81802804,81801251);the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital(No.2020-YQPY-007);the Natural Science Foundation of Hainan Province,China(No.821QN389,821MS112,822MS198,820MS126,820QN383);the National Key R&D Program of China(No.2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China(No.YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China(No.YSPTZX202216);the Medical Big Data R&D Project of Chinese People's Liberation Army General Hospital(No.MBD2018030);the China Postdoctoral Science Foundation Funded Project(No.2019M650359,2020M682816,2021T140298);the Heatstroke Treatment and Research Center of Chinese People's Liberation Army,the Simulation Training for Treatment of Heat Stroke;the Major Science and Technology Programme of Hainan Province,China(No.ZDKJ2019012).

摘　　要：Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.

关 键 词：ATM development cognitive 

分 类 号：R589[医药卫生—内分泌]