Potential risk genes for primary Sjogren's syndrome from a meta-analysis by linear regression and random forest classification  

作　　者：Tomas Cerdo Teresa Torres Moral 

机构地区：[1]Maimonides Biomedical Research Institute of Cordoba(IMIBIC),Reina Sofia University Hospital,University of Cordoba,Cordoba 14004,Spain [2]Centre for Rheumatology Research,Division of Medicine,University College London,London W1T 4JF,UK [3]Faculty of Computer Sciences,Multimedia and Telecommunication,Universitat Oberta de Catalunya,Barcelona 08018,Spain [4]Dermatology Department,Melanoma Unit,August Pi i Sunyer Biomedical Research Institute(IDIBAPS),and Hospital Clinic,Barcelona 08036,Spain [5]Center for Networked Biomedical Research on Rare Diseases(CIBERER),Carlos II Health Institute,Madrid 28029,Spain

出　　处：《Genes & Diseases》2024年第3期128-131,共4页基因与疾病（英文）

基　　金：Tomas Cerdo was supported by'Sara Borrell'programmes(CD21/00187)from the Institute of Health Carlos III(ICIII).

摘　　要：Primary Sjogren's syndrome(psS)is one of the most widespread autoimmune diseases with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands and the production of anti-SSA/Ro and anti-SSB/La antibodies that cause dysfunction and destruction mainly of salivary and lachrymal glands,leading to dry eyes and dry mouth.In the absence of a standardized evidence-based screening tool to decide which patients with dry eye must be referred for study of this pathology.

关 键 词：SJOGREN LYMPHOCYTIC SALIVARY 

分 类 号：R593[医药卫生—内科学]