Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations  

作　　者：Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad Akram Khan Chujiang Xu Jingxing Dai Jun Ouyang 

机构地区：[1]Guangdong Provincial Key Laboratory of Medical Biomechanics&National Key Discipline of Human Anatomy,Schoolof BasicMedical Sciences,Southern Medical University,Guangzhou,Guangdong 510515,China [2]Department of Laboratory Medicine,Nanfang Hospital of Southern Medical University,Guangzhou,Guangdong 510515,China [3]Department of Pathology,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong 510080,China [4]Department of Breast Surgery,Guangxi Medical University Cancer Hospital,Nanning,Guangxi 530000,China [5]Department of Veterinary Pathology,Faculty of Veterinary and Animal Sciences,PMAS Arid Agriculture University,Rawalpindi 46300,Pakistan [6]Department of Orthopedics,TCM-Integrated Hospital,Southern Medical University,Guangzhou,Guangdong 510000,China

出　　处：《Genes & Diseases》2024年第3期136-139,共4页基因与疾病（英文）

基　　金：supported bythe National Key R&D Program of China(No.2022YFF1202603);the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110440);the National Natural Science Foundation of China(No.82002779);the Guangxi Provincial Natural Science Foundation of China(No.2019GXNSFAA245083);the China Postdoctoral Science Foundation(No.2022M710853);the President's Foundation of the TCM-integrated Hospital of Southern Medical University(No.1202103001).

摘　　要：Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout life.However,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.

关 键 词：alterations INJURIES MASSIVE 

分 类 号：R318[医药卫生—生物医学工程] TP212[医药卫生—基础医学]