Distinct enhancer-promoter modes determine Sox2 regulation in mouse pluripotent cells  

作　　者：Lei Huang Xiusheng Zhu Qing Li Dashuai Kong Qitong Huang Jing Luo Siyuan Kong Yanling Peng Yubo Zhang 

机构地区：[1]Animal Functional Genomics Group,Shenzhen Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Key Laboratory of Livestock and Poultry Multi-omics of MAPA,Shenzhen Agricultural Genome Research Institute,Chinese Academyof Agricultural Sciences,Shenzhen,Guangdong 518120,China [2]Animal Breeding and Genomics,Wageningen University&Research,Wageningen 6708PB,Netherlands [3]College of Life Science and Engineering,Foshan University,Foshan,Guangdong 528231,China [4]School of Life Sciences,Henan University,Kaifeng,Henan 475004,China

出　　处：《Genes & Diseases》2024年第1期26-29,共4页基因与疾病（英文）

基　　金：supported by the National Key Research and Development Program of China(No.2018YFA0903201);the National Natural Science Foundation of China(No.32202653 and 31970592);the Agricultural Science and Technology Innovation Program(33-AGIS-07);the China Postdoctoral Science Foundation(No.BX2021367 and 2021M703543);the Guangdong Basic and Applied Basic ResearchFoundation(No.2022A1515010766);the Shenzhen Science and Technology Program(No.KCXFZ2020122-1173205015 and RCBS20210609104512021).

摘　　要：Sox2 is a key transfer factor for maintaining pluripotency and self-renewal in embryonic stem cells(ESCs),1 though the mechanism of its transcriptional regulation in ESCs has not been fully addressed.Distal enhancer-promoter interactions are vital for Sox2 transcription activity in mammals.However,how these diverse interactions individually influence Sox2 gene regulation in mouse ESCs remains unclear.Previous studies found that three distal enhancers(termed E1,E2,and E3)interact with Sox2 promoter?(Fig.1A;Fig.S1A,and Table S1).

关 键 词：SOX2 REGULATION DISTAL 

分 类 号：Q25[生物学—细胞生物学]