Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways  

作　　者：Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu 

机构地区：[1]Key Laboratory of Orthopaedics&Traumatology,Lingnan Medical Research Center,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510000,China [2]Department of Orthopaedics&Traumatology,Faculty of Medicine,The Chinese University of Hong Kong,Prince of Wales Hospital,Shatin,Hong Kong SAR 999077,China [3]Departments of Diagnostics of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510000,China [4]Orthopaedic Research Lab,Affiliated Hospital of Guangdong Medical University,Guangdong Medical University,Zhanjiang,Guangdong 524001,China

出　　处：《Genes & Diseases》2024年第1期64-66,共3页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81871778,81874000,82272505).

摘　　要：Fractures have an extraordinarily negative impact on individuals'quality of life and functional status.Nonunion or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new bone.The use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关 键 词：PI3K/AKT HIF1Α HEALING 

分 类 号：R683[医药卫生—骨科学]