Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment  

作　　者：Ouyang Yue Xuechuan Wang Mengdi Hou Siwei Sun Manhui Zheng Xiaoliang Zou Zhongxue Bai Chunlin Liu Xinhua Liu 

机构地区：[1]College of Bioresources Chemical and Materials Engineering,Shaanxi University of Science&Technology,Xi’an 710021,China [2]College of Pharmacy,Shaanxi University of Chinese Medicine,Xi’an 710021,China [3]Institute of Basic and Translational Medicine,Xi’an Medical University,Xi’an 710021,China [4]School of Mechanical Engineering,Chengdu University,Chengdu 610000,China

出　　处：《Nano Research》2024年第5期4359-4370,共12页纳米研究（英文版）

基　　金：supported by Fellowship of China Postdoctoral Science Foundation(No.2023M732159);the National Natural Science Foundation of China(Nos.22308209 ,2207081675);Key R&D Program of Shaanxi Province(No.2022GY-272);Young Talent Support Program Project of Shaanxi University Science and Technology Association(No.20200424).

摘　　要：Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive healthcare.Herein,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains.The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound closure.DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair capability.Furthermore,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies.This strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and necrosis.Therefore,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy.

关 键 词：electroactive bio-adhesive quadruple energy dissipation comprehensive wound therapy postoperative wound-status warning and assessment 

分 类 号：R318[医药卫生—生物医学工程]