Engineered plant extracellular vesicles for autoimmune diseases therapy  

作　　者：Ruina Han Yan Wu Yafei Han Xiangfei Liu Han Liu Jiacan Su 

机构地区：[1]Institute of Translational Medicine,Shanghai University,Shanghai 200444,China [2]Organoid Research Center,Shanghai University,Shanghai 200444,China [3]National Center for Translational Medicine(Shanghai)SHU Branch,Shanghai University,Shanghai 200444,China [4]Department of Orthopedics,Shanghai Zhongye Hospital,Shanghai 200941,China [5]Department of Orthopedics,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

出　　处：《Nano Research》2024年第4期2857-2873,共17页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82230071,and 82202344);Integrated Project of Major Research Plan of National Natural Science Foundation of China(No.92249303);Shanghai Committee of Science and Technology Laboratory Animal Research Project(No.23141900600).

摘　　要：Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy tissues.Plant extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive molecules.Due to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of AID.This review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechanisms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in AID.Additionally,we propose engineering approaches and administration methods for PEVs.Finally,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of AID.By gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for AID.Natural and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AID treatment.

关 键 词：autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]