有机磷阻燃剂2-乙基己基二苯基磷酸酯的污染现状及毒性效应研究进展  

Research progress on pollution status and toxic effects of organophosphorus flame retardants 2-ethylhexyl diphenyl phosphate

作　　者：张学艳 张天薇 李静 Zhang Xueyan;Zhang Tianwei;Li Jing(School of Public Health and Management,Jiangsu Vocational College of Medicine,Yancheng 224005,China;Key Laboratory of Human Genetics and Environmental Medicine,Xuzhou Medical University,Key Laboratory of Environment and Health,Xuzhou Medical University,Engineering Research Innovation Center of Biological Data Mining and Healthcare Transformation,Xuzhou Medical University,School of Public Health,Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]江苏医药职业学院公共卫生与管理学院,盐城224005 [2]徐州医科大学人类遗传和环境医学重点实验室,徐州医科大学环境与健康重点实验室,徐州医科大学生物数据挖掘与医疗健康转化创新工程研究中心,徐州医科大学公共卫生学院,徐州221004

出　　处：《中华劳动卫生职业病杂志》2024年第3期224-231,共8页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金青年基金(81703260);江苏省普通高校研究生科研、实践创新计划(KYCX21_2725);国家自然科学基金面上项目(82373609);江苏省高校"青蓝工程"项目(20220104)。

摘　　要：有机磷阻燃剂(OPFRs)造成的环境污染和健康危害已引起世界各国的广泛关注。2-乙基己基二苯基磷酸酯(EHDPP)作为一种典型的OPFR, 广泛存在于生产和生活中, 在水体、大气、土壤等环境介质中均可检出, 对生态环境和人群健康都产生较大风险。本文综述了国内外EHDPP研究进展, 从职业暴露、环境暴露与人群暴露角度概述EHDPP污染现状, 归纳和总结了EHDPP的毒性效应与机制, 包括急性毒性、肝脏毒性、神经毒性、生殖发育毒性及其致癌作用, 对今后EHDPP毒性作用与健康风险的研究方向提出展望, 为进一步研究EHDPP的环境危害与安全评价提供理论基础。The environmental pollution and health hazards caused by the extensive use of organophosphorus flame retardants(OPFRs)have become a problem of wide concern around the world.As a typical OPFR,2-ethylhexyl diphenyl phosphate(EHDPP)can be detected in water,atmosphere,soil and other environmental media.It widely exists in production and life and can accumulate in organisms,causing great risks the ecosystem and human health.This paper reviews the research of EHDPP domestically and abroad,and summarizes the physicochemical properties of EHDPP and the population situation of occupational exposure,environmental exposure,and population exposure in recent years.Besides,it summarizes the toxic effects and mechanisms of EHDPP,including acute toxicity,hepatotoxicity,neurotoxicity,reproductive and developmental toxicity,and carcinogenesis effects.This paper also proposes the future direction of toxicity and health risks of EHDPP,which provides a theoretical basis for further research on environmental hazards and safety evaluation of EHDPP.

关 键 词：环境暴露 有机磷酸酯 阻燃剂 2-乙基己基二苯基磷酸酯 毒性效应 职业暴露 

分 类 号：R994.6[医药卫生—毒理学]