慢性鼻窦炎患者鼻窦分泌物的需氧菌分离鉴定及药敏研究  

Isolation and identification of aerobic bacteria from nasal sinus secretion of patients with chronic sinusitis and study on drug sensitivity

作　　者：王红艳 丁晓林 张博 Wang Yanhong;Ding Xiaolin;Zhang Bo(Laboratory of Dongchangfu Maternal and Child Health Care Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市东昌府区妇幼保健院,山东聊城252000

出　　处：《中国医学文摘（耳鼻咽喉科学）》2024年第2期113-115,共3页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的 探讨慢性鼻窦炎患者鼻窦分泌物的需氧菌分离鉴定及药敏情况,指导患者合理应用抗生素进行治疗。方法 遵循随机原则,选择2021年1月~2022年1月在我院确诊为慢性鼻窦炎的75例患者,在手术实施中取鼻窦内脓性分泌物进行需氧菌培养及药敏试验,分析需氧菌株占比及药敏情况。结果 75例患者中45例发现细菌生长,阳性率为60.00%,分离出50株菌落,其中革兰氏阳性菌42株,占比84.00%;革兰氏阴性菌8株,占比16.00%;表皮葡萄球菌及金黄色葡萄球菌占比32.00%、28.00%。药敏试验显示需氧菌对左氧氟沙星(90.00%)、环丙沙星(87.50%)、万古霉素(100.00%)、庆大霉素(95.00%)、亚胺培南(45.00%)、利福平(100.00%)等抗生素敏感性较高,对青霉素(12.50%)、氨苄西林(25.00%)、阿奇霉素(10.00%)、红霉素(0.00%)敏感性较差。结论 慢性鼻窦炎入院后需要及时采集其鼻窦内分泌物进行细菌培养,结合培养结果及药敏试验,选择合适的抗生素对鼻窦炎进行治疗。Objective To investigate the isolation and identification of aerobic bacteria and drug sensitivity of nasal sinuses secretion from patients with chronic sinusitis,and guide patients to use antibiotics reasonably for treatment.Methods Following the principle of randomization,75 patients with chronic sinusitis diagnosed in our hospital from January 2021 to January 2022 were selected.During the operation,the purulent secretion in the sinuses was taken for aerobic bacteria culture and drug sensitivity test,and the proportion of aerobic bacteria and drug sensitivity were analyzed.Results Bacterial growth was found in 45 of the 75 patients,with a positive rate of 60.00%.50 colonies were isolated,of which 42 were Gram-positive bacteria,accounting for 84.00%;8 strains of Gram-negative bacteria,accounting for 16.00%;Staphylococcus epidermidis and Staphylococcus aureus accounted for 32.00%and 28.00%respectively.The drug sensitivity test showed that aerobic bacteria were highly sensitive to antibiotics such as levofloxacin(90.00%),ciprofloxacin(87.50%),vancomycin(100.00%),gentamicin(95.00%),imipenem(45.00%),rifampicin(100.00%),and other antibiotics,but were less sensitive to penicillin(12.50%),ampicillin(25.00%),azithromycin(10.00%),and erythromycin(0.00%).Conclusion After the admission of chronic sinusitis,it is necessary to collect the secretion in the sinuses in time for bacterial culture.Combined with the culture results and drug sensitivity test,appropriate antibiotics should be selected for the treatment of sinusitis.

关 键 词：慢性鼻窦炎 鼻窦分泌物 需氧菌分离鉴定 药敏 

分 类 号：R76[医药卫生—耳鼻咽喉科]