青竹标中大极性化学成分研究  

Highly polar chemical constituents from whole herb of Scindapsus officinalis

作　　者：赵磊[1] 耿炜 刘善庐 刘浩 张玉凯 岳涛 ZHAO Lei;GENG Wei;LIU Shan-lu;LIU Hao;ZHANG Yu-kai;YUE Tao(Shandong Chemical Technology Academy,Qingdao University of Science&Technology,Ji′nan 250014,China;Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University,Ji′nan 250014,China)

机构地区：[1]青岛科技大学山东化工研究院,山东济南250014 [2]青岛大学附属山东省妇幼保健院,山东济南250014

出　　处：《中国中药杂志》2024年第6期1558-1563,共6页China Journal of Chinese Materia Medica

基　　金：泰山学者建设工程项目(ts20130918)。

摘　　要：对青竹标水提物化学成分进行研究,运用大孔树脂柱色谱、MCI中压柱色谱、半制备型高效液相色谱等方法进行分离纯化,并结合化合物的理化性质和波谱学数据分析鉴定化合物结构,从青竹标水提取部位中分离并鉴定了10个化合物,分别为3,4⁃二羟基苯乙醇⁃8⁃O⁃[β⁃D⁃芹糖基(1→4)]⁃β⁃D⁃葡糖苷(1)、alternamide B(2)、3,4⁃二羟基苯乙醇葡萄糖苷(3)、1⁃(4⁃羟基)⁃苯乙基⁃β⁃D⁃吡喃半乳糖苷(4)、3,4⁃二羟基苯乙醇⁃8⁃O⁃[β⁃D⁃芹糖基(1→2)]⁃β⁃D⁃葡糖苷(5)、hydroxytyrosol⁃4⁃O⁃β⁃D⁃glu⁃copyranoside(6)、3,5⁃二羟基苯乙醇⁃3⁃O⁃β⁃D⁃葡糖苷(7)、红景天苷(8)、dihydroisoquinolone(9)、4⁃methoxybenzenepropanol⁃3⁃O⁃β⁃D⁃glucopyranoside(10)。其中化合物1为新化合物,化合物2~10均为首次从青竹标中分离得到。利用脂多糖(LPS)诱导RAW264.7细胞建立炎症模型,结果表明化合物6、7有较强的抗炎活性,化合物1、2、5具有中等抗炎活性。Macroporous resin column chromatography,MCI medium pressure column chromatography,and semi⁃preparative high performance liquid chromatography were employed to isolate the chemical components from the aqueous extract of the whole herb of Scindapsus officinalis.The structures of the compounds were identified based on the physical and chemical properties and the spectro⁃scopic data.Ten compounds were isolated from the aqueous extract and identified as 3,4⁃dihydroxyphenylethyl⁃8⁃O⁃[β⁃D⁃apiofurano⁃syl⁃(1→4)]⁃β⁃D⁃glucopyranoside(1),alternamide B(2),3,4⁃dihydroxyphenylethyl⁃O⁃β⁃D⁃glucopyranoside(3),1⁃(4⁃hydroxy)⁃phenylethyl⁃β⁃D⁃galactopyranoside(4),3,4⁃dihydroxyphenylethyl⁃8⁃O⁃[β⁃D⁃apiofuranosyl⁃(1→2)]⁃β⁃D⁃glucopyranoside(5),hydroxytyrosol⁃4⁃O⁃β⁃D⁃glucopyranoside(6),3,5⁃dihydroxyphenylethyl⁃3⁃O⁃β⁃D⁃glucopyranoside(7),salidroside(8),dihydroiso⁃quinolone(9),and 4⁃methoxybenzenepropanol⁃3⁃O⁃β⁃D⁃glucopyranoside(10).Among them,compound 1 was a new one,and com⁃pounds 2⁃10 were obtained from S.officinalis for the first time.The RAW264.7 cells were exposed to lipopolysaccharide for the mode⁃ling of inflammation,and the cells were then used to examine anti⁃inflammatory activities of the compounds.The results showed that compounds 6 and 7 had strong anti⁃inflammatory activities,while compounds 1,2,and 5 had moderate anti⁃inflammatory activities.

关 键 词：青竹标 化学成分 分离 抗炎活性 

分 类 号：R29[医药卫生—民族医学]