生物节律与子痫前期的相关性  

The Relationship between Biological Rhythm and Preeclampsia

作　　者：彭兰[1] 柏婷 周丽屏[1] 虞燕霞(审校)[1] PENG Lan;BAI Ting;ZHOU Li-ping;YU Yan-xia(The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215000,Jiangsu Province,China)

机构地区：[1]南京医科大学附属苏州医院,215000

出　　处：《国际妇产科学杂志》2024年第2期157-160,175,共5页Journal of International Obstetrics and Gynecology

基　　金：苏州市科技发展计划项目(SKY2022056);南京医科大学姑苏学院科研项目(GSKY20220410)。

摘　　要：子痫前期(preeclampsia,PE)是一种常见的妊娠并发症,危害母婴健康,更是一个严重的国际公共卫生问题。尽管已证实PE的高危因素包括肥胖、糖尿病和妊娠前高血压等,但其发病机制仍未完全阐明。哺乳动物中绝大多数的生理过程由生物节律调控,生物节律的破坏被证实与众多疾病相关,如心血管疾病、糖尿病和乳腺癌等。尽管PE具有一系列时间生物节律的特征性表现,如PE患者的血压24 h节律变异性、“反勺状”血压与更严重的靶器官损伤有关、夜间服用阿司匹林的预防保护作用更优异等,但生物节律的变异是否为PE的危险因素,抑或PE本身是否与异常的生物节律相关,目前尚未明确。综述生物节律与PE的相关性,包括胎盘的钟基因表达及其与PE的关系、血压的生物节律、PE预防的时间治疗学、生物节律的破坏与PE风险性,以启示今后深入研究生物节律/钟基因与PE之间潜在关联的必要性。Preeclampsia(PE)is a common complication of pregnancy and serious international public health problem,which endangering maternal and infant health.Although risk factors for PE have been demonstrated to include obesity,diabetes,and pre-pregnancy hypertension,its pathogenesis has not been fully elucidated.The vast majority of physiological processes in mammals are regulated by biological rhythm,and the disruption of biological rhythm has been shown to be associated with numerous diseases,such as cardiovascular disease,diabetes and breast cancer.Although PE is characterized by a series of biological rhythm,such as 24-hour variability in blood pressure in PE patients,"reversed nocturnal"blood pressure is associated with more severe target organ damage of PE,and superior prophylactic protection with nocturnal aspirin administration.The question of whether variation in biological rhythm is a risk factor for PE,or PE is associated with abnormal biological rhythm has not yet been clarified.The correlation between biorhythms and PE through literature study,including the expression of clock genes in the placenta and its relationship with PE,the biological rhythm of blood pressure,chronotherapy in the prevention of PE and disruption of biological rhythm and the risk of PE,in order to enlighten the necessity of further study on the potential association between biorhythms/circadian clock gene and PE in the future.

关 键 词：生物节律 先兆子痫 昼夜节律 时间治疗学 钟基因 

分 类 号：R714.244[医药卫生—妇产科学]