非自杀性自伤抑郁患者非酶类抗氧化物、血脂水平及焦虑抑郁症状的关联性  

Association study of non-enzyme antioxidant and lipid levels and anxiety and depressive symptoms in non-suicidal self-injury depressed patients

作　　者：许梦婷 房茂胜 XU Mengting;FANG Maosheng(School of Mental Health and Psychological Science,Anhui Medical University,Hefei 230032,China;Wuhan Mental Health Center,Wuhan 430012,China;Wuhan Hospital for Psychotherapy,Wuhan 430012,China)

机构地区：[1]安徽医科大学精神卫生与心理科学学院,合肥230032 [2]武汉市精神卫生中心,武汉430012 [3]武汉市心理医院,武汉430012

出　　处：《济宁医学院学报》2024年第2期90-94,共5页Journal of Jining Medical University

基　　金：国家自然科学基金资助项目(81771445)。

摘　　要：目的 探讨非自杀性自伤(NSSI)抑郁患者非酶类抗氧化物与血脂水平及焦虑抑郁症状的相互关联性。方法 回顾性选取2022年9月至2023年9月于武汉市精神卫生中心住院治疗的102例抑郁发作患者,分为伴NSSI行为的抑郁发作患者(NSSI组)54例作为研究组,不伴NSSI行为的抑郁发作患者(非NSSI组)48例作为对照组。比较伴与不伴NSSI行为的青少年抑郁患者的非酶类抗氧化物(TBiL、DBiL、ALB、UA)、血脂指标(TC、TG、HDL-C、LDL-C)的水平,以分析NSSI抑郁患者非酶类抗氧化物和血脂指标表达情况。结果 与对照组相比,研究组血清TBiL、DBiL、UA水平均较低(P<0.05),血清HDL-C水平较高(P<0.05)。家庭关系和睦(P=0.016,OR=6.925,95%CI:1.438-33.349)、抑郁水平(P<0.001,OR=1.215,95%CI:1.106-1.335)为青少年抑郁患者发生NSSI的独立危险因素。结论 NSSI抑郁患者可能存在氧化应激和血脂水平异常,且家庭关系和睦和抑郁水平是其独立危险因素。Objective To explore the correlation between non-enzymatic antioxidants and blood lipid levels and anxiety and depression symptoms in depressed patients with non-suicidal self-injury(NSSI).Methods Retrospectively,among 102 patients with depressive episode who were hospitalized in Wuhan Mental Health Center from September 2022 to September 2023,54 patients with depressive episode(NSSI group) and 48 patients with depressive episode without NSSI group(non-NSSI group) were selected as the research group and the control group respectively.Compare the levels of non-enzymatic antioxidants(TBiL,DBiL,ALB,UA),and blood lipid indexes(TC,TG,HDL-C,LDL-C) in adolescents with depression without NSSI behavior,to analyze the expression of non-enzymatic antioxidants and blood lipid indexes in NSSI depression patients;Associated analysis of non-enzymatic antioxidants(TBiL,DBiL,ALB,UA) and lipid indexes(TC,TG,HDL-C,LDL-C).Results Compared with the control group,serum TBIL,DBIL,UA in the study group were lower(P<0.05) and higher HDL-C(P<0.05).Family harmony(P=0.016,OR=6.925,95%CI:1.438-33.349) and depression lovel score(P<0.001,OR=1.215,95%CI:1.106-1.335) were independent risk factors for NSSI in adolescent depression.Conclusion Non-suicidal depressed patients may have oxidative stress and abnormal blood lipid levels,and harmonious family relationships and depressive symptoms are their independent risk factors.

关 键 词：非自杀性自伤 氧化应激 非酶类抗氧化物 血脂 抑郁 焦虑 

分 类 号：R473.1[医药卫生—护理学]