干扰素基因刺激因子激动剂的研究进展  

Research progress of STING agonists

作　　者：王娅 吴硕 李玉环[1] WANG Ya;WU Shuo;LI Yu-huan(Beijing Key Laboratory of Antimicrobial Agents,Key Laboratory of Antiviral Drugs Research,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,中国医学科学院抗病毒药物研究重点实验室,抗感染药物研究北京市重点实验室,北京100050

出　　处：《中国药理学通报》2024年第4期611-618,共8页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金青年项目(No 81803592);中国医学科学院医学与健康科技创新工程项目(No 2021-1-I2M-030)。

摘　　要：cGAS-STING通路作为固有免疫系统的重要组成部分,可以识别来自病原微生物和宿主细胞的胞质DNA,诱导Ⅰ型干扰素的分泌和炎症细胞因子的生成,激活机体免疫系统,抵抗病原微生物的入侵及增强机体抗肿瘤活性等。该文简要介绍了cGAS-STING通路的生物学功能,主要聚焦于STING激动剂的研究进展,包括CDN类和Non-CDN类STING激动剂的药理作用及其研究阶段,总结与展望STING激动剂研发过程中的问题与挑战,以期为后续相关药物的研发和疾病治疗提供思路。As an important part of the innate immune system,the cGAS-STING pathway can recognize cytoplasmic DNA from pathogenic microorganisms and host cells,induce the secretion of type Ⅰ interferon and the production of inflammatory cytokines,activate the immune system,resist the invasion of pathogenic microorganisms,and enhance antitumor activity.Here we briefly introduce the mechanism and biological functions of the cGAS-STING pathway,focus on the current research progress of STING agonists,including the pharmacological effects and research stages of STING CDN and Non-CDN agonists,and finally summarizes and prospects the problems and challenges in the research of STING agonists,in order to provide ideas for the development of related drugs and disease treatment.

关 键 词：cGAS-STING通路 免疫应答 STING激动剂 Ⅰ型干扰素 抗肿瘤免疫 抗感染免疫 

分 类 号：R392.11[医药卫生—免疫学] R394.2[医药卫生—基础医学] R457.2R730.5R978.7