硫酸软骨素蛋白多糖在脊髓损伤中的研究进展  

Research progress of chondroitin sulfate proteoglycans in spinal cord injury

作　　者：刘永 史永强 毛鹏 张海鸿[1] Liu Yong;Shi Yongqiang;Mao Peng;Zhang Haihong(Department of Orthopedics,The Second Hospital of Lanzhou University/Key Laboratory of Bone and Joint Diseases of Gansu Province)

机构地区：[1]兰州大学第二医院骨科/甘肃省骨关节疾病研究重点实验室,兰州730030

出　　处：《重庆医科大学学报》2024年第3期231-236,共6页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:31960175)。

摘　　要：硫酸软骨素蛋白多糖(chondroitin sulfate proteoglycans,CSPGs)是中枢神经系统细胞外基质的组成部分,在中枢神经系统发育、正常维持及病理过程中都发挥着关键的作用。脊髓损伤后,损伤部位CSPGs的表达明显上调,这主要源于病变部位活化的星形胶质细胞。CSPGs的上调会限制脊髓损伤部位的轴突再生、传导和再髓鞘化,并且可以促进脊髓损伤中的炎症反应,不利于脊髓损伤后神经功能恢复。因此,抑制CSPGs可能是促进脊髓损伤后轴突再生和功能恢复的有效治疗方法。本文对CSPGs在脊髓损伤中的研究现状进行综述。Chondroitin sulfate proteoglycans(CSPGs) are components of the extracellular matrix of the central nervous system,and play key roles in the development,function maintenance,and pathological process of the central nervous system.After spinal cord injury,the expression of CSPGs at the injury site is significantly upregulated,which is mainly due to activated astrocytes at the lesion site.Upregulation of CSPGs can restrict axon regeneration,conduction,and re-myelination at the site of spinal cord injury,and can promote the inflammatory response in spinal cord injury,which impedes the recovery of nerve function after spinal cord injury.Therefore,inhibition of CSPGs may be an effective treatment to promote axonal regeneration and functional recovery after spinal cord injury.This study reviews the current status of research on CSPGs in spinal cord injury.

关 键 词：硫酸软骨素蛋白多糖 脊髓损伤 糖胺聚糖 神经修复 

分 类 号：R651.2[医药卫生—外科学]