One-step co-doping of ZnO and Zn^(2+)in osteoinductive calcium phosphate ceramics with synergistic antibacterial activity for regenerative repair of infected bone defect  

作　　者：Tinghan He Hongxu Chen Puxin Liu Hao Shi Xiujuan Xu Cong Feng Yuyi Wang Xiangfeng Li Ning Lei Yumei Xiao Xiangdong Zhu Jianguo Xu Xingdong Zhang 

机构地区：[1]National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu 610064,China [2]College of Materials and Chemistry&Chemical Engineering,Chengdu University of Technology,Chengdu 610059,China [3]Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Journal of Materials Science & Technology》2023年第32期168-181,共14页材料科学技术（英文版）

基　　金：the National Key Research and Development Program of China(Grant No.2022YFC2401801);National Science Foundation of China(Grant No.52002256);Major Project of Sichuan Science and Technology Department(Grant Nos.2022ZDZX0029 and 2021YFS0032);Sichuan University“Zero to one”Innovation Research Project(Grant No.2022SCUH0044).

摘　　要：How to endow bone grafts with long-term antibacterial activity and good bone regenerative ability to achieve the regenerative repair of infected bone defects has been the focus of the clinical treatment of osteomyelitis.The present study introduced a novel one-step route to realizing the co-doping of zinc oxide(ZnO)and zinc ion(Zn^(2+))in biphasic calcium phosphate(BCP)ceramics to utilize their synergistic antibacterial.Compared with the conventional BCP ceramics(BCP-Ca),the ZnO/Zn^(2+)co-doping ones(BCP-Zn)possessed strong antibacterial ability on E.coli and S.aureus as well as stimulated the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)effectively.The synergistic antibacterial mechanism of ZnO and Zn^(2+)was also investigated.BCP-Zn showed excellent osteoinductivity and angiogenesis at three months postoperatively in the canine intramuscular implantation model.Moreover,BCP-Zn exhibited excellent anti-infective ability and bone regenerative repair compared to BCP-Ca and control groups in the infected bone defect model of rat femur.Collectively,these findings suggest that the simultaneous introduction of ZnO/Zn^(2+)could have immense potential to expand the application of osteoinductive BCP ceramics in the regenerative repair of infected bone defects.

关 键 词：Biphasic calcium phosphate ceramics Zinc oxide Zinc ion Antibacterial ability OSTEOINDUCTIVITY 

分 类 号：TB383.1[一般工业技术—材料科学与工程]