2022年北京航天总医院细菌耐药性监测  

The Surveillance of Bacterial Resistance in Beijing Aerospace General Hospital in 2022

作　　者：孟祥兆 邢国征 赵光轮 徐婷 周小凤 李世红 于洪远[1] MENG Xiangzhao;XING Guozheng;ZHAO Guanglun;XU Ting;ZHOU Xiaofeng;LI Shihong;YU Hongyuan(Department of Laboratory Medicine,Beijing Aerospace General Hospital,Beijing 100076,China)

机构地区：[1]北京航天总医院检验科,北京丰台100076

出　　处：《标记免疫分析与临床》2024年第2期208-213,291,共7页Labeled Immunoassays and Clinical Medicine

基　　金：北京航天总医院创新基金科研立项(编号2023-720)。

摘　　要：目的监测2022年北京航天总医院临床分离到的菌株对抗菌药物的耐药性。方法采用自动化鉴定及药敏仪器对从临床样本培养分离到的细菌菌株进行体外抗菌药物敏感性试验,参照2021年美国临床和实验室标准化协会(CLSI)推荐的药敏试验方法标准判读结果,用WHONET 5.6软件进行数据统计分析。结果2022年临床分离细菌共3261株,分离自呼吸道标本最多,占60.07%。其中革兰阳性菌982株,约占30.11%,葡萄球菌属544株,占革兰阳性菌的55.40%,肠球菌属338株,占革兰阳性菌34.42%,链球菌属31株。革兰阴性菌共2279株,占69.89%,其中肠杆菌属1222株,占革兰阴性菌的53.62%,非发酵菌1017株,占革兰阴性菌的44.62%。分离率前5名的菌株依次为肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌、鲍曼不动杆菌、屎肠球菌。耐甲氧西林金黄色葡萄球菌(MRSA)的检出率为22.86%,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率为75.07%,未发现万古霉素耐药的葡萄球菌。肺炎克雷伯菌对亚胺培南和美岁培南的耐药率分别为42.9%和67.0%,大肠埃希菌对亚胺培南和美罗培南的耐药率较低。铜绿假单胞菌对亚胺培南和美岁培南的耐药率分别为30.9%和28.0%,鲍曼不动杆菌对碳青霉烯类抗生素的耐药率高达60%以上。结论2022年北京航天总医院分离到的临床常见病原菌仍以革兰阴性细菌为主,碳青霉烯耐药的肺炎克雷伯菌和碳青霉烯耐药的鲍曼不动杆菌检出率较高。Objective To monitor the antimicrobial resistance of clinical isolates from Beijing Aerospace General Hospital in 2022.Methods The in vitro antimicrobial susceptibility test of bacteria isolated from clinical samples was carried out by using automatic identification and drug sensitivity instrument.Data analysis was conducted with WHONET 5.6,referring to the standard interpretation of the method of susceptibility testing recommended by the 2021 American Association for Clinical and laboratory standardization(CLSI).Results Atotal of 3261 strains of bacteria were isolated in 2022.The most common bacteria were isolated from respiratory tract(60.07%).Among all strains,982 strains were Gram-positive bacteria(30.11%),544 Staphylococcus bacteria(55.40%),338 enterococci(34.42%)and 31 Streptococcus.There were 2279 strains of Gram-negative bacteria(69.89%),including 1222 strains of Enterobacteriaceae(53.62%)and 1017 strains of non-fermentative bacteria(44.62%).The top five isolates were Klebsiella pneumoniae,Pseudomonas aeruginosa,Escherichia coli,acinetobacter baumannii and Enterococcus faecium.The detection rate of methicillin-resistant Staphylococcus aureus staphylococcus(MRSA)and methicillin-resistant coagulase-negative Staphylococcus(MRCNS)were 22.86%and 75.07%,respectively.No Vancomycin resistant Staphylococcus was found.The resistance rates of Klebsiella pneumoniae to imine and meropenem were 42.9%and 67.0%,respectively.The resistance rates of Escherichia coli to imipenem and Meropenem were lower.The resistance rates of Pseudomonas aeruginosa to imine penem and meropenem were 30.9%and 28.0%,respectively,and acinetobacter Bowman to Carbapenem antibiotics were more than 60%.Conclusion Gram-negative bacteria remain as the most common pathogens isolated from patients in Beijing Aerospace General Hospital in 2022.The detection rates of carbapenem-resistant Klebsiella pneumoniae and Carbapenem resistant Acinetobacter baumannii are high.

关 键 词：细菌耐药性监测 体外药物敏感性 多重耐药菌 碳青霉烯耐药 

分 类 号：R378[医药卫生—病原生物学]