内源性二氧化硫对血管的调控作用研究现状  

Research status on the regulation of endogenous sulfur dioxide on blood vessels

作　　者：宋运佳 钟晴 张蓉 孙许涛[1] SONG Yun-jia;ZHONG Qing;ZHANG Rong;SUN Xu-tao(School of Basic Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang Province,China)

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040

出　　处：《中国临床药理学杂志》2024年第7期1085-1088,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82204792);中国博士后科学基金资助项目(2022M711089);黑龙江省博士后基金资助项目(LBH-Z21080);黑龙江省卫生健康委基金资助项目(20210202010178);黑龙江省自然科学基金资助项目(YQ2022H020)。

摘　　要：二氧化硫(SO_(2))参与调节血管多种生理过程,如维持正常血管结构、调节血管张力、控制血压、抑制血管平滑肌细胞增殖,调节其凋亡和自噬。在高血压、肺动脉高压和动脉粥样硬化等血管疾病中,SO_(2)通过不同的分子机制对上述病理变化起到保护作用。本文将围绕内源性SO_(2)的生成代谢、血管生物学效应及其对血管的调控作用进行综述。Sulfur dioxide(SO_(2))is involved in regulating various physiological processes of blood vessels,such as maintaining normal vascular structure,regulating vascular tension,controlling blood pressure,inhibiting vascular cell proliferation,regulating apoptosis and autophagy.In pathophysiological conditions such as hypertension,pulmonary hypertension and atherosclerosis,SO_(2) plays a protective role in pathological changes through different molecular mechanisms.In this paper,we wll review the endogenous SO_(2) production and metabolism,vascular biological effects and its regulation on blood vessels.

关 键 词：二氧化硫 血管 高血压 肺动脉高压 动脉粥样硬化 

分 类 号：R97[医药卫生—药品]