矽肺患者血浆肺表面活性蛋白A表达与病情分期的关系  

Relationship between plasma SP-A expression level and disease stage in silicosis patients

作　　者：陈铿铿[1] 张碧珠[1] 彭颖仪 刘志芳[1] 陈晓燕[1] 金佳纯[1] CHEN Kengkeng;ZHANG Bizhu;PENG Yingyi;LIU Zhifang;CHEN Xiaoyan;JIN Jiachun(Department of Occupational Medical Laboratory and Health Monitoring,Guangdong Provincial Institute of Occupational Disease Prevention and Control,Guangzhou,Guangdong 510300,China)

机构地区：[1]广东省职业病防治院职业医学检验科及健康监护所,广东广州510300

出　　处：《上海预防医学》2024年第2期203-206,共4页Shanghai Journal of Preventive Medicine

基　　金：广东省医学科研资助基金(B2021134,A2021228)。

摘　　要：【目的】探讨矽肺患者血浆肺表面活性蛋白⁃A(SP⁃A)表达水平与矽肺病变的关系,为探索SP⁃A可否作为矽肺临床监测病情进展情况的生物标志物提供前期依据。【方法】2019年11月—2020年11月在广东省职业病防治院收集187例矽肺患者样本。采集矽肺组人群血样,采用酶联免疫吸附法测定血浆中SP⁃A水平。【结果】矽肺期组间SP⁃A水平比较,差异有统计学意义(P<0.05),其中矽肺Ⅲ期患者的血浆SP⁃A水平比Ⅰ期、Ⅱ期升高,差异有统计学意义(P<0.05)。吸烟对血浆SP⁃A水平有影响,年龄、工龄和饮酒均对血浆SP⁃A水平无影响。【结论】矽肺患者血浆中SP⁃A的表达水平升高,与病情分期具有一定相关性,在矽肺的发生发展中起一定的预警作用,可望成为矽肺患者诊断及预后的潜在生物标志物。[Objective]To investigate the relationship between plasma surfactant protein⁃A(SP⁃A)expression level and silicosis progression,and to provide early evidence for exploring whether SP⁃A can be used as a biomarker for clinical monitoring of silicosis disease progression.[Methods]We recruited 187 silicosis patients in Guangdong Province hospital for occupational disease prevention and treatment between November,2019 and November,2020.Their peripheral venous blood samples were collected for the plasma isolation.The level of pulmonary SP⁃A was detected by enzyme-linked immunosorbent assay.[Results]There was a statistically significant difference in the level of SP⁃A among the silicosis groups(P<0.05),and the plasma SP-A level of the silicosis patients in stageⅢwas higher than that in stageⅠand stageⅡ(P<0.05).Smoking had effect on plasma SP⁃A levels,Age,working years and drinking had no effect on plasma SP⁃A levels.[Conclusion]The expression level of SP⁃A in the plasma of silicosis patients is increased,which has a certain correlation with the disease stage,and plays a certain early warning role in the occurrence and development of silicosis,and may be a potential biomarker for the diagnosis and prognosis of silicosis.

关 键 词：矽肺 生物标志物 肺表面活性蛋白⁃A 病情分期 

分 类 号：R135.2[医药卫生—劳动卫生]