亚抑菌浓度抗菌药物影响金黄色葡萄球菌生物膜形成的研究进展  

Research progress in the effect of sub-minimum inhibitory concentration of antimicrobial agents on the biofilm formation of Staphylococcus aureus

作　　者：张晓润 宋爽[1] 朱丽莹[1] 王文静 陶臻[1] ZHANG Xiao-run;SONG Shuang;ZHU Li-ying;WANG Wen-jing;TAO Zhen(Department of Infectious Diseases,Nanjing First Hospital,Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学附属南京医院/南京市第一医院感染性疾病科,江苏南京210000

出　　处：《中国感染控制杂志》2024年第4期538-543,共6页Chinese Journal of Infection Control

基　　金：南京医科大学科技发展基金一般项目(NMUB20220080)。

摘　　要：金黄色葡萄球菌(SA)是引起医院获得性感染的常见病原体之一,极易黏附在导管或植入物表面形成生物膜导致耐药性增加,给临床治疗带来极大挑战。近年研究表明,抗菌药物处于亚抑菌浓度时可影响SA生物膜形成。因此,本文阐述SA生物膜的形成过程及基因调控,不同抗菌药物在亚抑菌浓度下对SA生物膜形成的影响及其作用机制,以期为有效控制及治疗SA生物膜相关感染提供一定依据。Staphylococcus aureus(SA)is one of the common pathogens causing healthcare-associated infection,which easily adheres to the surface of catheters or implants to form biofilm,leading to increased antimicrobial resis-tance,and posing great challenge to clinical treatment.In recent years,studies have shown that antimicrobial agents at sub-minimum inhibitory concentration(sub-MIC)can affect the biofilm formation of SA.This paper elaborates the formation process and gene regulation of SA biofilm,as well as the effect and mechanisms of different antimicrobial agents at sub-MIC on SA biofilm formation,so as to provide basis for effective control and treatment of SA biofilm-related infection.

关 键 词：亚抑菌浓度 抗菌药物 金黄色葡萄球菌 生物膜形成 作用机制 

分 类 号：R378.11[医药卫生—病原生物学]