线粒体功能障碍与血管钙化发生的研究进展  

Mitochondrial Dysfunction and the Development of Vascular Calcification

作　　者：丁姝颖 于子翔[1] 马依彤[1] DING Shuying;YU Zixiang;MA Yitong(Heart Center of The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐830054

出　　处：《心血管病学进展》2024年第3期253-256,共4页Advances in Cardiovascular Diseases

基　　金：新疆维吾尔自治区天山英才培养计划项目(2022TSYCLJ0001)。

摘　　要：血管钙化是在衰老、动脉粥样硬化、慢性肾脏病和糖尿病中普遍存在的病理现象。线粒体DNA损伤、高磷酸盐浓度和线粒体自噬异常等均可通过改变线粒体功能影响血管钙化的发生和发展。目前线粒体功能障碍在血管钙化过程中的作用机制尚未完全明确,现探讨线粒体功能障碍在调控血管钙化中的作用和相关机制,为临床治疗血管钙化提供思路。Vascular calcification is a prevalent pathological phenomenon in senescence,atherosclerosis,chronic kidney disease and diabetes mellitus.Mitochondrial DNA damage,alterations in the mitochondrial microenvironment and abnormal mitochondrial autophagy can affect the occurrence and development of vascular calcification by altering mitochondrial function.The role of mitochondrial dysfunction in the process of vascular calcification has not been fully elucidated yet.In this paper,we will explore the role of mitochondrial dysfunction and related mechanism in regulating vascular calcification,and provide therapeutic ideas for clinical treatment of vascular calcification.

关 键 词：血管钙化 血管平滑肌细胞 线粒体功能障碍 

分 类 号：R543[医药卫生—心血管疾病]