SIRT1介导的信号通路在阿霉素诱导心脏毒性中的作用机制  

The Mechanisms of SIRT1-Mediated Signal Pathway in Doxorubicin-Induced Cardiotoxicity

作　　者：李登科 张伟[1] 黄从新[1] LI Dengke;ZHANG Wei;HUANG Congxin(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute,Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院心内科/武汉大学心血管病研究所/心血管病湖北省重点实验室,湖北武汉430060

出　　处：《心血管病学进展》2024年第3期257-260,共4页Advances in Cardiovascular Diseases

基　　金：湖北省技术创新专项(2016ACA153)。

摘　　要：沉默信息调节因子1(SIRT1)通过介导多种信号通路参与调节氧化应激、线粒体功能、细胞凋亡、炎症反应、内质网应激、纤维化等病理生理过程,在阿霉素诱导的心脏毒性中发挥保护作用。现总结SIRT1介导的信号通路在阿霉素诱导心脏毒性中的作用机制。Silence information regulator 1(SIRT1)plays a protective role in doxorubicin-induced cardiotoxicity by mediating a variety of signaling pathways to participate in the regulation of oxidative stress,mitochondrial function,apoptosis,inflammatory response,endoplasmic reticulum stress,fibrosis and other pathological and physiological processes.This review summarizes the mechanisms of SIRT1-mediated signaling pathways in doxorubicin-induced cardiotoxicity.

关 键 词：沉默信息调节因子1 信号通路 阿霉素 心脏毒性 

分 类 号：R96[医药卫生—药理学]