基于计算流体力学的个性化Stanford B型主动脉夹层血流动力学研究  

Hemodynamic study of personalized Stanford type B aortic dissection based on computational fluid dynamics

作　　者：王仕奇 王凌云[1] 林志鸿 朱鹏 杨谦 陈江华[4] WANG Shiqi;WANG Lingyun;LIN Zhihong;ZHU Peng;YANG Qian;CHEN Jianghua(Department of Mechanical and Electrical Engineering,Xiamen University,Xiamen,361100,Fujian,P.R.China;Department of Cardiovascular Surgery,Nanfang Hospital,Southern Medical University,Guangzhou,510515,P.R.China;Department of Cardiovascular Surgery,Xiamen Cardiovascular Hospital,Xiamen University,Xiamen,361004,Fujian,P.R.China;Department of Color Ultrasound,Zhongshan Hospital Affiliated to Xiamen University,Xiamen,361004,Fujian,P.R.China)

机构地区：[1]厦门大学机电工程系,福建厦门361100 [2]南方医科大学南方医院心血管外科,广州510515 [3]厦门大学附属心血管病医院心血管外科,福建厦门361004 [4]厦门大学附属中山医院彩超科,福建厦门361004

出　　处：《中国胸心血管外科临床杂志》2024年第4期594-599,共6页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：福建省卫生教育联合攻关计划项目(WKJ2016-2-21)。

摘　　要：目的建立个性化Stanford B型主动脉夹层数值模拟模型,利用计算流体力学(computational fluid dynamics,CFD)数值模拟的方法探究B型主动脉夹层发展不同阶段的血流动力学行为以及规律。方法基于三维模型重建理论,通过厦门大学附属心血管病医院1例B型主动脉夹层患者的CT图像,利用相关医学图像处理软件进行重构个性化主动脉三维模型。利用CFD对重构的模型进行流体力学仿真。结果三维重建模型可以直观地观察夹层发展不同阶段假腔的变化趋势。通过流体力学仿真得到夹层发展不同阶段的血液流速、压力、壁面剪切应力、血管壁Von Mises应力等多个参数的变化规律。结论分析相关参数在夹层发展阶段的血流动力学行为和规律,结合临床医学检测,能够反映疾病发展情况,最终为主动脉夹层的科学诊断提供更多的理论和方法。Objective To establish a personalized Stanford type B aortic dissection numerical simulation model,and using computational fluid dynamics(CFD)numerical simulation to obtain the hemodynamic behavior and law of the type B aortic dissection at different stages of development.Methods Based on the theory of three-dimensional model reconstruction,we used CT images of a patient with type B aortic dissection in the Xiamen Cardiovascular Hospital of Xiamen University,relevant medical image processing software to reconstruct a personalized aortic three-dimensional model,and CFD to reconstruct the model which was simulated in fluid mechanics.Results The three-dimensional reconstruction model could intuitively observe the changing trend of the false cavity at different stages of the dissection development.Through fluid mechanics simulation,the blood flow rate,pressure,wall shear stress,vascular wall Von Mises stress and other parameters at different stages of the dissection development were obtained.Conclusion The hemodynamic behavior and law of relevant parameters in the development stage of aortic dissection are analyzed.The combination of the values of relevant parameters and clinical medical detection and diagnosis can well predict the development of the disease,and finally provide more theories and methods for the scientific diagnosis of aortic dissection.

关 键 词：计算流体力学 主动脉夹层 血流动力学 流固耦合 

分 类 号：R543.1[医药卫生—心血管疾病]