An Automated,Highly Selective Reaction Monitoring Instrument Using Molecular Rotational Resonance Spectroscopy  

作　　者：Ann Adele Byars Khushi R.Kompally Emily Mechnick Reilly E.Sonstrom Alexander Mikhonin Justin L.Neill Ruth Boetzel James MacGregor Courtney Talicska Jian Li Yizhou Liu 

机构地区：[1]BrightSpec,Inc.,Charlottesville,Virginia 22903,United States [2]Pfizer R&D UK Limited,Sandwich CT139NJ,United Kingdom [3]Analytical Research and Development,Pfizer Research and Development,Groton,Connecticut 06340,United States

出　　处：《Precision Chemistry》2024年第2期57-62,共6页精准化学（英文）

摘　　要：Online monitoring of chemical reactions by using analytical chemistry tools is a powerful way to maximize control over these processes.In this paper,we demonstrate the use of molecular rotational resonance,an emerging and extraordinarily selective spectroscopic technique,to perform automated reaction monitoring measurements.An interface using a six-port valve with a calibrated sample loop,coupled to a temperature controlled inlet for analyte volatilization,was developed and tested.Two reactions were chosen for initial characterization:an amine-aldehyde condensation reaction to form an imine product and an isotopic exchange reaction of aβ-ketoester with keto-enol tautomerization.The spectrometer was able to provide kinetic information about the reaction and determine reaction completion.In the future,this system can be extended to detect and quantify impurities and characterize reaction selectivity,in addition to the reaction progress.

关 键 词：molecular rotational resonance spectroscopy reaction monitoring reaction kinetics ISOTOPES process analytical technology 

分 类 号：O62[理学—有机化学]