Making topological protein links using enzymatic reactions  

作　　者：Roger Castells-Graells Todd O.Yeates 

机构地区：[1]Department of Chemistry and Biochemistry,University of California,USA [2]UCLA-DOE Institute for Genomics and Proteomics,USA

出　　处：《National Science Review》2024年第3期44-45,共2页国家科学评论（英文版）

摘　　要：Proteins are exceedingly complex molecules though,at their heart,they are essentially linear polymers.Pull at their ends and one obtains an extended backbone.While that is true in most cases,some natural proteins have evolved elaborations that complicate the picture.These modifications typically stabilize a natively folded conformation and prevent its unfolding.Numerous structural and chemical mechanisms for embellishing the protein backbone have been elucidated,ranging from simple disulfide bonds to much more complex topological features.

关 键 词：TOPOLOGICAL BACKBONE BONDS 

分 类 号：Q51[生物学—生物化学]