银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面的疗效观察  

Effects of Silver Ion Dressing Combined with Compound Polymyxin B Ointment in the Treatment of Deep Second-Degree Burn Infectious Wounds

作　　者：马雅宁 赵鹏 孟素玉 徐文虎 胡荔男 王康 MA Yaning;ZHAO Peng;MENG Suyu;XU Wenhu;HU Linan;WANG Kang(Department of Burn and Plastic Surgery,Xingtai City Fifth Hospital,Xingtai 054000,Hebei,China)

机构地区：[1]邢台市第五医院烧伤整形科,河北邢台054000

出　　处：《中国美容医学》2024年第4期25-29,共5页Chinese Journal of Aesthetic Medicine

基　　金：邢台市重点研发计划项目(编号:2022ZC209)。

摘　　要：目的:探讨银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面的疗效。方法:选取149例深Ⅱ度烧伤感染性创面患者,依照乱数表法分为观察组(n=75例)和对照组(n=74例),对照组给予复方多粘菌素B软膏治疗,观察组在对照组基础上加用银离子敷料治疗。统计比较两组创面恢复相关指标、创面疼痛程度、血清炎性因子和疼痛介质水平、临床疗效及瘢痕情况。结果:治疗后,观察组感染控制时间、住院时间、创面愈合时间均短于对照组(P<0.05),治疗21 d后的创面愈合率高于对照组(P<0.05)。观察组治疗后各时间点疼痛评分均低于对照组(P<0.05);治疗21 d后,观察组血清C反应蛋白、白介素-6、神经肽Y、前列腺素E2水平均低于对照组(P<0.05),创面愈合总有效率高于对照组(P<0.05);创面愈合后6个月,观察组温哥华瘢痕量表各评分及总分均低于对照组(P<0.05)。结论:银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面能促进创面愈合,减轻创面疼痛程度,并能有效抑制血清炎性因子、疼痛介质水平,减轻创面瘢痕程度,提升创面美学效果。Objective To explore the effects of silver ion dressing and compound polymyxin B ointment in the treatment of burn infectious wounds.Methods A total of 149 patients with deep partial-thickness burn infection wounds were selected and divided into observation group(n=75)and control group(n=74)according to the random number table method.The control group was treated with compound polymyxin B ointment,and the observation group was treated with silver ion dressing on the basis of the control group.The wound recovery related indicators,wound pain degree,serum inflammatory factors and pain mediators levels,clinical efficacy and scar condition were statistically compared between the two groups.Results After treatment,the infection control time,hospitalization time,and wound healing time in the observation group were shorter than those in the control group(P<0.05),and the wound healing rate after 21 days of treatment was higher than that in the control group(P<0.05).The pain scores of the observation group were lower than those of the control group at each time point after treatment(P<0.05).After 21 days of treatment,the serum levels of C-reactive protein,interleukin-6,neuropeptide Y,and prostaglandin E2 in the observation group were lower than those in the control group(P<0.05),and the total effective rate of wound healing was higher than that in the control group(P<0.05).Six months after wound healing,each score and total score of Vancouver Scar Scale in the observation group were lower than those in the control group(P<0.05).Conclusion Silver ion dressing combined with compound polymyxin B ointment in the treatment of deep partial-thickness burn infected wounds can promote wound healing,reduce wound pain,effectively inhibit the levels of serum inflammatory factors and pain mediators,reduce wound scar,and improve wound aesthetic effect.

关 键 词：银离子敷料 复方多粘菌素B软膏 深Ⅱ度烧伤感染性创面 炎性因子 瘢痕 

分 类 号：R644[医药卫生—外科学]