PRP联合曲安奈德局部注射及瘢痕组织瓣修复术治疗瘢痕疙瘩疗效分析  

Analysis of the Efficacy of Topical Injection of Triamcinolone and Scar Tissue Flap Repair in the Treatment of Keloids

作　　者：刘丹[1] 李茂玉[1] 吴丹 LIU Dan;LI Maoyu;WU Dan(Department of Medical Cosmetology,Suining Central Hospital,Suining 629000,Sichuan,China)

机构地区：[1]遂宁市中心医院医疗美容科,四川遂宁629000

出　　处：《中国美容医学》2024年第4期79-82,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:分析富血小板血浆(Platelet-rich plasma,PRP)联合曲安奈德局部注射及瘢痕组织瓣修复术治疗瘢痕疙瘩的美学效果。方法:选取2017年2月-2021年11月遂宁市中心医院医疗美容科收治的瘢痕疙瘩患者85例,遵随机数字表法分为曲安奈德组42例(瘢痕组织瓣修复术联合曲安奈德局部注射)和联用PRP组43例(曲安奈德组基础上联合PRP治疗)。比较两组临床疗效,瘢痕恢复情况,疼痛及瘙痒情况和复发率,记录两组不良反应发生情况。结果:治疗后,联用PRP组治疗总有效率为97.67%,显著高于曲安奈德组的85.71%(P<0.05);治疗后,两组色泽、柔软度、血管及厚度评分均降低(P<0.05),且联用PRP组显著低于曲安奈德组(P<0.05);治疗后,两组疼痛及瘙痒评分均降低(P<0.05),且联用PRP组显著低于曲安奈德组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05);随访1年后,联用PRP组总复发率为2.33%,显著低于曲安奈德组的14.29%(P<0.05)。结论:PRP联合曲安奈德局部注射联合瘢痕组织瓣修复术治疗瘢痕疙瘩疗效确切,能有效促进瘢痕创面恢复,缓解疼痛及瘙痒,降低复发率。Objective To analyze the cosmetic effect of platelet-rich plasma(PRP)combined with topical injection of triamcinolone and scar tissue flap repair in the treatment of keloids.Methods 85 patients with keloid treated in department of medical cosmetology of Suining Central Hospital from February 2017 to November 2021 were selected and divided into 42 cases in triamcinolone group(scar tissue flap repair combined with topical injection of triamcinolone)and 43 cases in united PRP group(PRP on the basis of triamcinolone group)according to the random number table method.The clinical efficacy,scar recovery,pain and pruritus and recurrence rate were compared between the two groups,and the adverse reactions were recorded in the two groups.Results After treatment,the total effective rate of treatment in united PRP group was 97.67%,which was significantly higher than 85.71%in triamcinolone group(P<0.05).The scores of color,softness,blood vessel and thickness were decreased in both groups after treatment(P<0.05),and the scores were significantly lower in united PRP group than those in triamcinolone group(P<0.05).After treatment,the scores of pain and pruritus were reduced in the two groups(P<0.05),and the scores in united PRP group were significantly lower compared to triamcinolone group(P<0.05).There were no statistically significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).After 1 year of follow-up,the total recurrence rate in united PRP group was 2.33%,which was significantly lower than 14.29%in triamcinolone group(P<0.05).Conclusion PRP combined with topical injection of triamcinolone and scar tissue flap repair in the treatment of keloids has an exact efficacy,and it can effectively promote the recovery of scar wound,relieve the pain and pruritus,and reduce the recurrence rate.

关 键 词：富血小板血浆 曲安奈德 瘢痕疙瘩 瘢痕组织瓣修复术 

分 类 号：R619.6[医药卫生—外科学]