一种复合型生物消毒液抗菌活性及其安全性研究  

Study on antibacterial activity and safety of a compound biological disinfectant

作　　者：刘冠 严敏 杜锡林 邵中军 LIU Guan;YAN Min;DU Xi-lin;SHAO Zhong-jun(The Second Affiliated Hospital of Air Force Military Medical University of Chinese PLA,Xi’an Shannxi 710000,China)

机构地区：[1]中国人民解放军空军军医大学第二附属医院,陕西西安710000

出　　处：《中国消毒学杂志》2024年第3期161-164,共4页Chinese Journal of Disinfection

摘　　要：目的 观察一种以抗菌肽(AMP)和聚六亚甲基双胍(PHMB)为主要成分的复合型生物消毒液抗菌活性及其安全性。方法 采用悬液定量杀菌试验和动物试验方法,对某复合型生物消毒液抗菌活性及其安全性进行观察。结果 该复合生物消毒液原液对悬液内的指示菌分别作用1 min,对金黄色葡萄球菌、大肠埃希菌和铜绿假单胞菌的平均杀灭对数值均>5.0,对白念珠菌的平均杀灭对数值>4.0。该复合消毒液对小鼠LD50值>5 000 mg/(kg·bw),属实际无毒级;其原液对家兔完整皮肤和黏膜均无刺激性。结论 该复合型生物消毒液具有良好的杀菌效果和生物安全性。Objective To observe the antibacterial activity and safety of a compound biological disinfectant containing antimicrobial peptide(AMP)and polyhexamethylene biguanide(PHMB)as main components.Methods Suspension quantitative bactericidal test and animal test methods were used to observe the antibacterial activity and safety of the compound biological disinfectant.Results When incubated with the compound biological disinfectant for 1 min,the average killing log value of the disinfectant for Staphylococcus aureus,Escherichia coil and Pseudomonas aeruginosa were>5.0,and that were>4.0 for Candida albicans.The LD50 value of the disinfectant for mice was>5000 mg/(kg•bw),which belonged to a practical non-toxic level.The original solution of the disinfectant had no irritating effect to the intact skin and mucous membranes of rabbits.Conclusion The compound biological disinfectant has good antibacterial effect and biological safety.

关 键 词：抗菌肽 聚六亚甲基双胍 生物消毒液 杀菌效果 皮肤消毒 

分 类 号：R187.2[医药卫生—流行病学]