猪β-防御素129和114的表达及其功能研究进展  

Research Progress on the Expression and Function of Porcineβ-defensin 129 andβ-defensin 114

作　　者：李菊 黄晓刚 韩贝贝 刘松柏 高凤磊[2] 李莉 赵云翔 张守全 卫恒习 LI Ju;HUANG Xiaogang;HAN Beibei;LIU Songbo;GAO Fenglei;LI Li;ZHAO Yunxiang;ZHANG Shouquan;WEI Hengxi(National Engineering Research Center for Breeding Swine Industry,Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding,College of Animal Science,South China Agricultural University,Guangdong Guangzhou 510642,China;School of Tropical Agriculture and Forestry,Guangdong AIB Polytechnic,Guangdong Guangzhou 510507,China;School of Foshan University Life Sciences and Engineering,Guangdong Foshan 528000,China;Maoming sub-center,Guangdong Laboratory for Lingnan Modern Agriculture,Guangdong Maoming 525000,China)

机构地区：[1]华南农业大学动物科学学院,国家生猪种业工程技术研究中心,广东省农业动物基因组学与分子育种重点实验室,广东广州510642 [2]广东农工商职业技术学院热带农林学院,广东广州510507 [3]佛山科学技术学院生命科学与工程学院,广东佛山528000 [4]岭南现代农业科学与技术广东省实验室茂名分中心,广东茂名525000

出　　处：《中国畜牧杂志》2024年第3期73-78,共6页Chinese Journal of Animal Science

基　　金：广东省重点领域研发计划(2022B0202110002);广东省“珠江人才计划”本土创新科研团队(2019BT02N630);广东省农业厅乡村振兴战略专项(粤农农计[2022]39号)。

摘　　要：防御素是广泛分布于脊椎动物体内的高度保守的小型阳离子肽,具有抵抗病原微生物的能力,并在先天性免疫与适应性免疫中发挥重要作用。猪β-防御素129(Porcine β-Defensin 129,pBD129)和猪β-防御素114(Porcine β-Defensin,pBD114)广泛分布于猪的各个器官和组织中,它们除抵抗病原微生物、调节机体免疫功能外,还对猪的繁殖与发育具有重要作用。近年来研究表明,pBD129和pBD114在公猪附睾中有较高的表达量,并参与精子的成熟、运动和受精过程,对雄性动物的精子功能和受精能力具有重要影响。本文对pBD129和pBD114在猪体内的表达分布情况、参与调节的信号通路以及相关生物学功能等进行综述,旨在为pBD129和pBD114的功能研究和应用提供理论和参考依据。β-defensins are highly conserved small cationic peptide widely distributed in vertebrates,contributing to the antimicrobial action,innate and adaptive immunity.Porcineβ-defensin 129(pBD129)and porcineβ-defensin 114(pBD114)are widely distributed in various organs and tissues of pigs.In addition to resisting pathogenic microorganisms and regulating immune function,they also play an important role in reproductive development.pBD129 and pBD114 are highly expressed in the epididymis of boars.Recent works have confirmed that the involvement of these two defensins in the process of maturation,motility and fertilization of sperm.This paper reviews recent advances in pBD129 and pBD114,including the expression and distribution,signal pathways involved in,as well as related biological functions,in order to provide theoretical and reference basis for the functional study and application of pBD129 and pBD114.

关 键 词：pBD129 pBD114 免疫 繁殖 猪 

分 类 号：S828.2[农业科学—畜牧学]