肺超声评分联合血清白细胞介素-17检测在重症肺炎新生儿中的应用价值  

The Application Value of Pulmonary Ultrasound Score Combined with Serological Index Detection in Newborns with Severe Pneumonia

作　　者：梁远冰 梁正旭 LIANG Yuan-bing;LIANG Zheng-xu(Department of Ultrasound Medicine,Beiliu People's Hospital,Beiliu Guangxi,537400,China)

机构地区：[1]广西北流市人民医院超声医学科,广西北流537400

出　　处：《中华养生保健》2024年第9期173-176,共4页CHINESE HEALTH CARE

摘　　要：目的探讨与分析肺超声评分(lung ultrasound scoring,LUS)联合血清白细胞介素-17(IL-17)检测在新生儿重症肺炎中的应用价值。方法选取2019年2月—2023年1月在广西北流市人民医院(新生儿科)诊治的重症肺炎新生儿84例作为研究对象,所有患儿都给予肺超声评价与IL-17检测,判断呼吸衰竭的发生情况并进行预测价值分析。结果在84例患儿中,判断为呼吸衰竭24例,占比28.60%(呼吸衰竭组),其余为非呼吸衰竭组。呼吸衰竭组的肺超声评分显著高于非呼吸衰竭组,呼吸衰竭组的血清IL-17含量显著高于非呼吸衰竭组。含量显著高于非呼吸衰竭组,差异有统计学意义(P<0.05)。在84例患儿中,肺超声评分检测预测重症肺炎新生儿发生呼吸衰竭的敏感度为78.40%,特异度为5.4%,血清IL-17含量检测预测重症肺炎新生儿发生呼吸衰竭的敏感度为81.40%,特异度为82.60%,联合指标检测预测重症肺炎新生儿发生呼吸衰竭的敏感度为85.70%,特异度为82.60%;受试者操作特征曲线(ROC曲线)分析显示肺超声评分、血清IL-17含量与联合指标检测预测重症肺炎新生儿发生呼吸衰竭的最大ROC曲线下面积分别为0.782、0.814、0.887,有一定的预测准确性。结论重症肺炎新生儿中呼吸衰竭的发生率比较高,可导致肺超声评分增加与血清IL-17释放增加,肺超声评分联合血清学指标检测在重症肺炎新生儿中的应用能有效预测呼吸衰竭的发生。Objective To explore and analysis the application values of lung ultrasound scoring(LUS)combined with serological indicators detection in newborns with severe pneumonia.Methods From February 2019 to January 2023,84 cases of neonates with severe pneumonia diagnosed and treated in Neonatal Intensive Care Unit(NICU)of a certain hospital were selected as the study subjects.All the neonates were given lung ultrasound evaluation and serum interleukin-17(IL-17)detection,and the occurrence of respiratory failure was recorded and the predictive value analysis of indices above was carried out.Results There were 24 cases diagnosed as respiratory failure(named after Respiratory failure group)in the 84 cases that accounted for 28.6%,with the others named after non Respiratory failure group.There were no significant differences in birth weight,age,length,gestational age,gender,delivery mode compared between Respiratory failure group and non Respiratory failure group(P>0.05).The lung ultrasonic scores of Respiratory failure group were significantly higher than that of non Respiratory failure group(P<0.05),and the serum IL-17 content of Respiratory failure group was significantly higher than that of non Respiratory failure group(P<0.05).In 84 children,the sensitivity of lung ultrasound score detection to predict respiratory failure of severe pneumonia newborns 78.4%,specificity of 5.4%,serum IL-17 content detection predicted the sensitivity of respiratory failure of severe pneumonia newborns 81.4%,specificity of 82.6%,combined index detection predicted the sensitivity of severe pneumonia newborns 85.7%,specificity of 82.6%.Receiver operating characteristic curve(ROC)curve analysis showed that the maximum area under the curve of pulmonary ultrasound score,serum IL-17 content and combined indices detected to predict respiratory failure in neonates with severe pneumonia were 0.782,0.814 and 0.887,which suggested certain predictive accuracy.Conclusion The incidence of respiratory failure in neonates with severe pneumonia was rela

关 键 词：重症肺炎 新生儿 呼吸衰竭 肺超声评分 白细胞介素-17 预测价值 

分 类 号：R563.1[医药卫生—呼吸系统]