核因子E2相关因子2信号通路在病理性瘢痕中作用的研究进展  

Research progress of nuclear factor E2-related factor 2 signaling pathway in pathological scar

作　　者：龚玲 李宇[1] 马娟[1] 迟宏羽 董祥林[1] Gong Ling;Li Yu;Ma Juan;Chi Hongyu;Dong Xianglin(Department of Plastic Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第一附属医院整形科,乌鲁木齐830011

出　　处：《中华整形外科杂志》2024年第3期343-348,共6页Chinese Journal of Plastic Surgery

基　　金：新疆维吾尔自治区青年基金项目(2019DOIC308)。

摘　　要：核因子E2相关因子2(Nrf2)是细胞维持氧化还原稳态的主要调节因子,Nrf2信号通路具有抗炎、抗氧化应激、抗纤维化等作用,在伤口愈合及病理性瘢痕形成及进展中起着重要作用。该文对氧化应激、Nrf2信号通路对病理性瘢痕作用的相关研究进行了综述,并对Nrf2信号通路、氧化应激和病理性瘢痕之间的相互关系进行了阐述,以为病理性瘢痕的机制研究及临床防治提供新的视角。Nuclear factor E2-related factor 2(Nrf2)is a major regulator of redox homeostasis in cells,and Nrf2 signaling pathway has anti-inflammatory,anti-oxidative stress,and anti-fibrosis effects while plays an important role in wound healing and pathological scar formation and progression.This article reviewed the related research regarding the effect of oxidative stress and Nrf2 signaling pathway on pathological scars,furthermore,it investigated the relationship between Nrf2 signaling pathway,oxidative stress and pathological scars,providing a new perspective for the study of mechanism and clinical prevention and treatments of pathological scars.

关 键 词：瘢痕 肥大性 瘢痕疙瘩 核因子E2相关因子2信号通路 活性氧 病理性瘢痕 伤口愈合 

分 类 号：R622[医药卫生—整形外科]