孕妇血清PLGF水平联合孕妇及胎儿血管参数预测胎儿生长受限  

Clinical study on predicting fetal growth restriction by combining maternal serum PLGF levels with maternal and fetal vascular parameters in pregnant women

作　　者：黄亮 丁太峰 黄旭 张丽君 HUANG Liang;DING Tai-feng;HUANG Xu;ZHANG Li-jun(Department of obstetrics,Kaifeng Obstetrics and Gynecology Hospital,Kaifeng 475000,Henan,China;不详)

机构地区：[1]开封市妇产医院产科,河南开封475000 [2]开封市妇产医院超声科,河南开封475000

出　　处：《广东医学》2024年第2期236-240,共5页Guangdong Medical Journal

基　　金：开封市科技发展计划项目(2203114)。

摘　　要：目的 探究孕妇血清胎盘生长因子(PLGF)水平联合孕妇及胎儿血管参数预测胎儿生长受限(FGR)的临床价值。方法 选取60例确诊为FGR的孕妇(FGR组)及60例产前检查健康的孕妇(健康组)。检测孕妇血清PLGF水平(以酶联免疫吸附法)。于孕20~24周对孕妇进行超声检查,检查孕妇子宫动脉(UtA)、胎儿大脑中动脉(MCA)、脐动脉(UA)阻力指数(RI)、搏动指数(PI)、收缩期/舒张期血流比值(S/D)等。绘制受试者工作特征(ROC)曲线评估孕妇血清PLGF水平联合孕妇及胎儿血管参数对FGR的预测价值。行多因素logistic回归分析影响FGR发生的因素。结果 FGR组UtA、UA的RI、PI、S/D明显高于健康组(P<0.05),血清PLGF、MCA的RI、PI、S/D明显低于健康组(P<0.05)。绘制ROC曲线评估血清PLGF联合孕妇及胎儿血管超声参数预测FGR发生的价值,结果显示,UtA-S/D、MCA-PI、UA-RI、UA-PI敏感度较高,PLGF、UA-S/D、MCA-S/D特异度较高,均在90%及以上;行多因素logistic回归分析显示,UtA-RI、UtA-PI、UtA-S/D、MCA-PI、MCA-S/D、UA-RI、UA-PI、UA-S/D、PLGF为影响FGR发生的因素(P<0.05)。结论 FGR孕妇血清PLGF水平较低,母胎血管参数异常,可作为临床预测FGR发生的潜在指标。Objective To investigate the clinical significance of combining maternal serum placental growth factor(PLGF)levels with maternal and fetal vascular parameters in predicting fetal growth restriction(FGR).Methods Sixty pregnant women diagnosed with FGR(FGR group)and 60 pregnant women with routine prenatal examinations(Healthy group)were selected.Maternal serum PLGF levels were measured using enzyme-linked immunosorbent assay.Ultra-sonography was performed on pregnant women at gestational weeks 20-24 to assess parameters including uterine artery(UtA),middle cerebral artery(MCA),and umbilical artery(UA)resistance index(RI),pulsatility index(PI),and systolic/diastolic blood flow ratio(S/D).ROC curves were plotted to evaluate the predictive value of maternal serum PL-GF levels combined with maternal and fetal vascular parameters for FGR.Multiple logistic regression analysis was conduc-ted to identify factors influencing the occurrence of FGR.Results The FCR group showed significantly higher RI,PI,and S/D in UtA and UA,while serum PLCF levels,as well as RI,PI,and S/D in MCA,were significantly lower com-pared to the Healthy group(P<0.05).ROC curve analysis indicated that UtA-S/D,MCA-PI,UA-RI,and UA-PI had high sensitivity,while PLCF,UA-S/D,and MCA-S/D exhibited high specificity,all exceeding 90%.Multiple logistic regression analysis revealed that UtA-RI,UtA-PI,UtA-S/D,MCA-PI,MCA-S/D,UA-RI,UA-PI,UA-S/D,and PLCF were factors influencing the occurrence of FCR(P<0.05).Conclusion Lower maternal serum PLGF levels and abnormal maternal-fetal vascular parameters can serve as potential indicators for predicting the occur-rence of FCR in pregnant women.

关 键 词：胎儿生长受限 血管参数 胎盘生长因子 预测价值 

分 类 号：R714.245[医药卫生—妇产科学] R446.1[医药卫生—临床医学]