软通道微创穿刺引流术联合七叶皂苷钠治疗33例高血压性脑出血的效果分析  

Effect of Soft-channel Minimally Invasive Puncture and Drainage Combined with Sodium Aesculin in the Treatment of 33 Patients with Hypertensive Cerebral Hemorrhage

作　　者：肖航 陈振兴 李斌 XIAO Hang;CHEN Zhenxing;LI Bin(Department of Neurosurgery,Changle District People's Hospital,Fuzhou,Fujian Province,350200 China)

机构地区：[1]福州市长乐区人民医院神经外科,福建福州350200

出　　处：《中外医疗》2024年第5期70-73,共4页China & Foreign Medical Treatment

摘　　要：目的探究软通道微创穿刺引流术联合七叶皂苷钠治高血压脑出血的临床效果。方法方便选取2020年1月—2022年9月福州市长乐区医院收治的66例高血压脑出血患者为研究对象,依据随机数表法将其分为两组,每组33例,对照组实施常规治疗,观察组实施软通道微创穿刺引流术联合七叶皂苷钠,对比两组相关指标。结果观察组治疗总有效率(96.97%)明显高于对照组(72.73%),差异有统计学意义(χ^(2)=7.543,P<0.05)。干预后,观察组脑水肿容量、神经功能较之对照组更低,差异有统计学意义(P均<0.05);干预后,观察组的水通道蛋白-4抗体(Aquaporin-4 Antibody,AQP4-Ab)、人细胞纤维连接蛋白(Human Cell Fibronectin,CPN)、超敏C反应蛋白(Hypersensitive C-reactive protein,hs-CPR)较之对照组更低,差异有统计学意义(P均<0.05)。结论对高血压脑出血患者实施软通道微创穿刺引流术联合七叶皂苷钠干预,患者的AQP4-Ab、Cfn、IL-6、hs-CRP得到明显调整,并改善患者神经功能缺损,缩小脑水肿面积,减少血肿量,加速其意识清醒,对其整体治疗有效率的提升有一定促进效果。Objective To explore the clinical effect of soft-channel minimally invasive puncture and drainage combined with sodium aesculin in the treatment of hypertensive cerebral hemorrhage.Methods 66 patients with hypertensive intracerebral hemorrhage admitted to Fuzhou Changle District Hospital from January 2020 to September 2022 were conveniently selected as the study objects.They were divided into two groups according to random number table method,with 33 cases in each group.The control group received conventional treatment,and the observation group received soft-channel minimally invasive puncture and drainage combined with sodium escinate,and the relevant indicators of the two groups were compared.Results The therapeutic total effective rate of observation group was 96.97%,which was higher than that of control group(72.73%),and the difference was statistically significant(χ^(2)=7.543,P<0.05).After intervention,the cerebral edema volume and nerve function in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After intervention,the aquaporin-4 antibody(AQP4-Ab),human cell fibronectin(Cfn)and hypersensitive C-reactive protein(hs-CRP)in the observation group were lower than those in the control group,and the difference was statistically significant(all P<0.05).Conclusion In patients with hypertensive intracerebral hemorrhage,soft-channel minimally invasive puncture and drainage combined with aesculin sodium intervention can significantly adjust AQP-Ab,Cfn,and hs-CRP of the patients,improve the neurological deficits of the patients,reduce the area of cerebral edema,reduce the amount of hematoma,and accelerate their consciousness.It has a certain promoting effect on the improvement of the overall treatment efficiency.

关 键 词：软通道微创穿刺引流术 七叶皂苷钠 高血压脑出血 

分 类 号：R4[医药卫生—临床医学]