放射治疗联合靶向疗法对非小细胞肺癌晚期患者临床有效性研究  

Clinical Efficacy of Radiotherapy Combined with Targeted Therapy in Advanced Patients with Non-small Cell Lung Cancer

作　　者：常威[1] 刘海鸿 CHANG Wei;LIU Haihong(Department of Oncology,Zibo Central Hospital,Zibo,Shandong Province,255022 China;Department of Traditional Chinese Medicine Surgery,Zibo Hospital of Traditional Chinese Medicine,Zibo,Shandong Province,255022 China)

机构地区：[1]山东省淄博市中心医院肿瘤科,山东淄博255022 [2]淄博市中医医院中医外科,山东淄博255022

出　　处：《中外医疗》2024年第5期98-101,共4页China & Foreign Medical Treatment

摘　　要：目的 研究放射治疗联合靶向疗法对非小细胞肺癌(Non-Small Cell Lung Cancer, NSCLC)晚期患者的临床有效性。方法 方便选取2022年6月—2023年6月山东省淄博市中心医院收治的96例非小细胞肺癌晚期患者为研究对象,采用随机数表法分为对照组和观察组,每组48例。对照组采用放射治疗,观察组采用放射治疗联合靶向疗法。比较两组疗效、肿瘤标志物、免疫功能、不良反应发生率。结果 观察组缓解率(56.25%)和疾病控制率(87.50%)高于对照组(35.42%、68.75%),差异有统计学意义(χ^(2)=4.196、4.937,P均<0.05)。治疗后,观察组细胞角蛋白19片段、癌胚抗原、糖类抗原199、CD8^(+)水平均低于对照组,CD4^(+)、CD3^(+)水平高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 放射治疗联合靶向疗法对非小细胞肺癌晚期患者治疗效果高,可获得更高的控制率,能有效下调细胞角蛋白19片段、癌胚抗原、糖类抗原199水平,调节免疫,且不增加不良反应。Objective To investigate the clinical efficacy of radiotherapy combined with targeted therapy in advanced non-small cell lung cancer(NSCLC)patients.Methods A total of 96 patients with advanced non-small cell lung cancer treated in the Central Hospital of Zibo City at Shandong Province from June 2022 to June 2023 were conveniently selected as the study objects,and they were divided into control group and observation group by random number table method,with 48 cases in each group.The control group received radiotherapy,and the observation group received radiotherapy combined with targeted therapy.The efficacy,tumor markers,immune function and incidence of adverse reactions were compared between the two groups.Results The remission rate(56.25%)and disease control rate(87.50%)in the observation group were higher than those in the control group(35.42%,68.75%),and the differences were statistically significant(χ^(2)=4.196,4.937,both P<0.05).After treatment,the levels of keratin 19 fragment,carcinoembryonic antigen,carbohydrate antigen 199 and CD8^(+)in observation group were lower than those in control group,and the levels of CD4^(+)and CD3^(+)were higher than those in control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Radiotherapy combined with targeted therapy has a high therapeutic effect on advanced non-small cell lung cancer patients,and can obtain a higher control rate.It can effectively down-regulate the levels of cytokeratin 19 fragment,carcinoembryonic antigen and carbohydrate antigen 199,and regulate immunity without increasing adverse reactions.

关 键 词：非小细胞肺癌 放射治疗 靶向疗法 

分 类 号：R5[医药卫生—内科学]