硫酸镁联合拉贝洛尔治疗妊娠高血压的效果及对收缩压、舒张压水平的影响  

Effect of Magnesium Sulfate Combined with Labetalol on Hypertensive Pregnancy and Its Influence on Systolic and Diastolic Blood Pressure

作　　者：李纪[1] LI Ji(Department of Gynecology and Obstetrics,Quanzhou Hospital of Traditional Chinese Medicine,Quanzhou,Fujian Province,362000 China)

机构地区：[1]福建省泉州市中医院产科,福建泉州362000

出　　处：《中外医疗》2024年第5期102-106,共5页China & Foreign Medical Treatment

摘　　要：目的 分析将硫酸镁联合拉贝洛尔治疗方案应用于妊娠高血压患者,对其收缩压、舒张压水平产生的影响。方法 回顾性选取2019年3月—2022年5月福建省泉州市中医院的100例妊娠高血压患者的临床资料,以治疗方法的不同分为两组,每组50例,接受硫酸镁常规治疗的为对照组,硫酸镁联合拉贝洛尔治疗的为观察组,比较两组临床疗效、血管内皮功能、血压水平、炎性应激反应、不良反应发生率以及不良结局发生率。结果 观察组临床疗效(98.00%)高于对照组(86.00%),差异有统计学意义(χ^(2)=4.891,P<0.05)。治疗后,观察组各项血管内皮功能指标均优于对照组,观察组血压水平均低于对照组,观察组各项炎性应激反应指标均优于对照组,观察组不良反应发生率及不良结局发生率均低于对照组,差异有统计学意义(P均<0.05)。结论 与常规治疗方案相比,硫酸镁基础上联合拉贝洛尔治疗妊娠高血压的效果更为显著。Objective To analyze the effects of magnesium sulfate combined with labetalol on systolic and diastolic blood pressure in hypertensive pregnancy patients.Methods Clinical data of 100 patients with gestational hypertension in Quanzhou Hospital of Traditional Chinese Medicine at Fujian Province from March 2019 to May 2022 were retrospectively selected.The patients were divided into two groups based on different treatment methods,with 50 cases in each group.Conventional treatment with magnesium sulfate was used as control group,and treatment with magnesium sulfate combined with labetalol was used as observation group.The clinical efficacy,vascular endothelial function,blood pressure,inflammatory stress response,incidence of adverse reactions and incidence of adverse outcomes were compared between the two groups.Results The clinical effect of observation group(98.00%)was higher than that of control group(86.00%),and the difference was statistically significant(χ^(2)=4.891,P<0.05).After treatment,all vascular endothelial function indexes in the observation group were better than those in the control group,blood pressure levels in the observation group were lower than those in the control group,and all inflammatory stress response indexes in the observation group were better than those in the control group,and the incidence of adverse reactions and adverse outcomes in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Compared with the conventional treatment,magnesium sulfate combined with labetalol in the treatment of pregnancy hypertension effect is more significant.

关 键 词：妊娠高血压 硫酸镁 拉贝洛尔 血管内皮功能 血压水平 不良反应 

分 类 号：R5[医药卫生—内科学]