鼻咽癌患者生命质量评价及其影响因素分析  

Evaluation of quality of life of nasopharyngeal carcinoma patients and analysis of influencing factors

作　　者：张娅妮 陈添良 罗添馨 冯晓红 万崇华 吴家园 胡利人 杜进林 杨铮 ZHANG Yani;CHEN Tianliang;LUO Tianxin;FENG Xiaohong;WAN Chonghua;WU Jiayuan;HU Liren;DU Jinlin;YANG Zheng(School of Public Health,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]广东医科大学公共卫生学院,广东东莞523808 [2]广东医科大学人文与管理学院 [3]广东医科大学附属医院临床试验服务中心

出　　处：《山东医药》2024年第11期21-26,共6页Shandong Medical Journal

基　　金：广东省普通高校重点科研平台和科研项目(2018KTSCX074)。

摘　　要：目的评价鼻咽癌患者的生命质量情况,并探讨其可能的影响因素。方法选择121例鼻咽癌患者,采用鼻咽癌患者生命质量测定量表QLICP-NA(V2.0)进行生命质量评价,包括躯体功能、心理功能、社会功能、共性症状与不良反应、特异模块五个领域。收集鼻咽癌患者的一般人口学资料(性别、年龄、婚姻状况等11个因素),采用多重线性回归分析其对患者生命质量的影响;收集鼻咽癌患者的15个临床客观指标[白蛋白(Alb)、球蛋白(G)、丙氨酸氨基转移酶(ALT)、总胆红素(TB)、总胆汁酸(TBA)、碱性磷酸酶(ALP)、γ-谷氨酰基转移酶(GGT)、尿素(BUN)、肌酐(Cr)、乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)、白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白(Hb)、血小板计数(PLT)],采用简单线性相关分析和典型相关分析观察其对患者生命质量的影响。结果鼻咽癌患者躯体功能评分(61.03±15.63)分、心理功能评分(60.95±15.35)分、社会功能评分(59.17±14.16)分、共性症状与不良反应评分(71.49±19.40)分、特异模块评分(75.62±14.87)分,量表总分(66.10±11.58)分。TNM分期是躯体功能、心理功能、社会功能评分和量表总分的独立影响因素,家庭经济状况是心理功能、社会功能评分的独立影响因素,年龄是量表总分的独立影响因素(P均<0.05)。躯体功能评分与Alb、TB、Cr、RBC、Hb呈正相关关系,心理功能评分与ALT、AST、Hb呈正相关关系,社会功能评分与ALT、RBC、Hb呈正相关关系,共性症状与不良反应评分与Alb、Cr、RBC、Hb呈正相关关系(P均<0.05);特异模块评分与RBC、Hb呈正相关关系,与ALT、LDH、AST呈负相关关系(P均<0.05)。典型相关分析自动提取的五对典型变量对中只有第一对的典型相关系数有统计学意义(典型相关系数为0.561,特征根所占百分比为41.26%,P<0.05),其临床客观指标中ALT、AST、Hb的标准化典型系数较大(分别为0.465、-0.Objective To assess the quality of life in patients with nasopharyngeal carcinoma and to investigate its possible mechanism.Methods A total of 121 patients with nasopharyngeal cancer were included in the study.The quality of life instrument for nasopharyngeal cancer patients QLICP-NA(V2.0)was used to evaluate their quality of life from the following five domains:physical functioning,psychological functioning,social functioning,common symptoms and adverse reactions,and specific modules.General demographic data(including 11 factors such as gender,age,and marital status,etc.)were collected,and multiple linear regression analysis was conducted to determine the effects of these variables on the patients'quality of life.Additionally,15 clinical objective indicators[albumin(Alb),globulin(G),alanine aminotransferase(ALT),total bilirubin(TB),total bile acids(TBA),alkaline phosphatase(ALP),γ-glutamyltransferase(GGT),urea(BUN),Cratinine(Cr),lactate dehydrogenase(LDH),aspartate aminotransferase(AST),white blood cell count(WBC),red blood cell count(RBC),hemoglobin(Hb),and platelets(PLT)]were collected and analyzed to determine their correlation and typical correlation with the patients'quality of life.Results The physical functioning score of nasopharyngeal carcinoma patients was 61.03±15.63,the psychological functioning score was 60.95±15.35,the social functioning score was 59.17±14.16,the common symptom and adverse reaction score was 71.49±19.40,the specific module score was 75.62±14.87,and the total score of the scale was 66.10±11.58,respectively.Clinical staging was an independent influencing factor for physical functioning,psychological functioning,social functioning scores,and the total scale score;family economic status was an independent influencing factor for psychological functioning and social functioning scores;age was an independent influencing factor for the total scale score(all P<0.05).The physical functioning score was positively correlated with Alb,TB,Cr,RBC,and Hb;the psychological functioning score

关 键 词：生命质量 鼻咽癌 TNM分期 

分 类 号：R762[医药卫生—耳鼻咽喉科]