宫腹腔镜手术联合富血小板血浆宫腔灌注对子宫内膜异位症不孕患者的影响  

Effect of Hysteroscopic and Laparoscopic Surgery Combined with Intrauterine Perfusion of Platelet Rich Plasma on Infertile Patients with Endometriosis

作　　者：林韶华 周舟 LIN Shaohua;ZHOU Zhou(Department of Obstetrics and Gynecology,the First People's Hospital of Nanning,Nanning 530022,China;不详)

机构地区：[1]南宁市第一人民医院妇产科,广西南宁530022

出　　处：《中国医学创新》2024年第9期26-30,共5页Medical Innovation of China

摘　　要：目的:探究宫腹腔镜手术联合富血小板血浆(PRP)宫腔灌注对子宫内膜异位不孕症患者的影响。方法:选取2020年1月—2022年11月在南宁市第一人民医院进行宫腹腔镜手术的86例子宫内膜异位症不孕患者,根据随机数字表法分成两组,即对照组和观察组均有43例患者,对照组患者术后给予醋酸亮丙瑞林微球治疗,观察组患者给予PRP治疗。比较两组患者的临床疗效,复发率,子宫内膜容受性,炎症因子及子宫内膜异位症生育指数(EFI)评分。结果:治疗前,两组患者的子宫内膜容受性、炎症因子水平、EFI评分对比,差异均无统计学意义(P>0.05),治疗后,两组患者的子宫动脉血流阻力指数及子宫动脉血流搏动指数及炎症因子水平对比,观察组均更低,观察组子宫内膜更厚,内膜容积更大,EFI评分更高,且观察组患者的临床总有效率更高,复发率更低,差异均有统计学意义(P<0.05)。结论:宫腹腔镜手术联合PRP宫腔灌注能够减轻子宫内膜异位症不孕患者术后的炎症反应,改善患者的子宫内膜容受性,进而提高患者的生育指数评分和临床疗效。Objective:To explore the effect of hysteroscopy and laparoscopy combined with uterine perfusion with platelet rich plasma(PRP)on infertile patients with endometriosis.Method:From January 2020 to November 2022,86 cases of endometriosis infertility patients who underwent hysteroscopy and laparoscopy in the First People's Hospital of Nanning were selected and divided into two groups according to the random number table method,namely control group and observation group,with 43 cases in each group.The control group was treated with Leuprolide Acetate Microspheres after surgery,and the observation group was treated with PRP.The clinical efficacy,recurrence rate,endometrial receptivity,inflammatory factors and endometriosis fertility index(EFI)scores were compared between the two groups.Result:Before treatment,there were no statistically significant differences in endometrial receptivity,inflammatory factor levels and EFI scores between the two groups(P>0.05).After treatment,the uterine artery blood flow resistance index,uterine artery blood flow pulsatility index and inflammatory factor levels were compared between the two groups of patients,those in the observation group were lower,the endometrium in the observation group was thicker,the endometrial volume in the observation group was larger,and the EFI score in the observation group was higher,and the total clinical effective rate of the observation group was higher,and the recurrence rate was lower,the differences were statistically significant(P<0.05).Conclusion:Hysteroscopic and laparoscopic surgery combined with intrauterine perfusion of PRP can reduce the inflammatory response of infertile patients with endometriosis after surgery,improve the endometrial receptivity of patients,and thus improve the fertility index score and clinical efficacy of patients.

关 键 词：宫腹腔镜手术 富血小板血浆 子宫内膜异位症 容受性 炎症因子 

分 类 号：R711[医药卫生—妇产科学]