比阿培南不同给药时间对急性脓毒症伴感染性休克患者疗效的影响  

Effect of Different Administration Time of Biapenem on the Therapeutic Effect in Patients with Acute Sepsis Complicated with Infectious Shock

作　　者：欧阳慕梅 李甜甜 张欢 OUYANG Mumei;LI Tiantian;ZHANG Huan(Department of Infectious Diseases,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China;不详)

机构地区：[1]九江市第一人民医院感染性疾病科,江西九江332000

出　　处：《中国医学创新》2024年第9期35-38,共4页Medical Innovation of China

摘　　要：目的:探讨比阿培南不同给药时间对急性脓毒症伴感染性休克患者疗效的影响。方法:选择2021年1月—2023年6月九江市第一人民医院感染性疾病科接收的急性脓毒症伴感染性休克患者70例作为研究对象,按照治疗方式分为两组。对照组(n=30)采取比阿培南常规30 min输注治疗,观察组(n=40)采取比阿培南2 h输注用药治疗。比较两组患者的临床效果及不良反应发生情况,评价治疗前、治疗后患者的健康状况评分,测定患者血常规指标。结果:观察组治疗有效率(95.00%)显著高于对照组(73.33%)(P<0.05)。观察组不良反应发生率(7.50%)与对照组(13.33%)比较,差异无统计学意义(P>0.05)。治疗后,观察组急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、序贯器官衰竭评估(SOFA)评分均显著低于对照组(P<0.05)。治疗后,观察组白细胞计数(WBC)、中性粒细胞(N)、降钙素原(PCT)、红细胞沉降率(ESR)、C反应蛋白(CRP)均显著低于对照组(P<0.05)。结论:与比阿培南常规30 min输注用药相比,延长2 h输注用药治疗急性脓毒症伴感染性休克可进一步提高治疗效果,抑制炎症反应,减轻患者器官功能损害,改善健康状况,而且延长用药时间不会增加不良反应,安全性高。Objective:To investigate the effect of different administration time of Biapenem on the therapeutic effect in patients with acute sepsis complicated with infectious shock.Method:A total of 70 patients with acute sepsis complicated with infectious shock admitted to the Department of Infectious Diseases,Jiujiang NO.1 People's Hospital from January 2021 to June 2023 were selected as the study objects and divided into two groups according to treatment methods.The control group(n=30)was treated by routine infusion of Biapenem for 30 min,and the observation group(n=40)was treated by infusion of Biapenem for 2 h.The clinical effects and the occurrence of adverse reactions were compared between the two groups,the health scores of the patients were evaluated before and after treatment,and the blood routine indexes of the patients were measured.Result:The effective rate of observation group(95.00%)was significantly higher than that of control group(73.33%)(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(7.50%)and the control group(13.33%)(P>0.05).After treatment,acute physiology and chronic health evaluationⅡ(APACHEⅡ)score and sequential organ failure assessment(SOFA)score in observation group were significantly lower than those in control group(P<0.05).After treatment,the white blood cell count(WBC),neutrophil(N),procalcitonin(PCT),erythrocyte sedimentation rate(ESR)and C reactive protein(CRP)in observation group were significantly lower than those in control group(P<0.05).Conclusion:Compared with the conventional 30 min infusion of Biapenem,the 2-hour extension of infusion for the treatment of acute sepsis complicated with infectious shock can further improve the therapeutic effect,inhibit the inflammatory response,reduce the organ function damage of patients,and improve the health status of patients.Moreover,the extension of administration time will not increase the adverse reactions,and has high safety.

关 键 词：脓毒症 感染性休克 比阿培南 

分 类 号：R969[医药卫生—药理学]