枸橼酸咖啡因注射液联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征的临床研究  

Clinical Study on the Combination of Caffeine Citrate Injection and Poractant Alfa Injection in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：高颖博 包莉娜 蒋琼 冯国仙 GAO Yingbo;BAO Lina;JIANG Qiong;FENG Guoxian(Department of Neonatology,Baiyun District Maternal and Child Health Hospital of Guangzhou,Guangzhou 510400,China;不详)

机构地区：[1]广州市白云区妇幼保健院新生儿科,广东广州510400

出　　处：《中国医学创新》2024年第9期47-51,共5页Medical Innovation of China

摘　　要：目的:探讨新生儿呼吸窘迫综合征联合应用枸橼酸咖啡因注射液、猪肺磷脂注射液治疗的效果。方法:抽取广州市白云区妇幼保健院2018年3月—2023年3月收治的新生儿呼吸窘迫综合征90例为研究对象,采用随机数字表法分为对照组和试验组,各45例,对照组行猪肺磷脂注射液治疗,试验组行枸橼酸咖啡因注射液+猪肺磷脂注射液治疗,观察两组动脉血气指标、炎症因子变化情况,并评估两组治疗效果及安全性。结果:(1)试验组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);(2)试验组治疗后氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))、氢离子浓度指数(pH)水平均显著优于对照组,差异均有统计学意义(P<0.05);(3)试验组治疗后白细胞介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均显著低于对照组,差异均有统计学意义(P<0.05);(4)试验组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05)。结论:针对新生儿呼吸窘迫综合征,予以枸橼酸咖啡因注射液+猪肺磷脂注射液治疗,可改善动脉血气,减轻机体炎症反应,提高疗效,且联合用药不增加不良反应发生率。Objective:To explore the therapeutic effect of combined use of Caffeine Citrate Injection and Poractant Alfa Injection on neonatal respiratory distress syndrome.Method:A total of 90 patients with neonatal respiratory distress syndrome admitted to Baiyun District Maternal and Child Health Hospital of Guangzhou from March 2018 to March 2023 were selected as the study subjects.They were divided into the control group and the experimental group using random number table method,with 45 cases in each group.The control group received treatment with Poractant Alfa Injection,while the experimental group received treatment with Caffeine Citrate Injection and Poractant Alfa Injection.The changes in arterial blood gas indicators and inflammatory factors in both groups were observed,and the treatment effects and safety of the two groups were evaluated.Result:(1)The total effective rate of the experimental group was significantly higher than that of the control group,the difference was statistically significant(P<0.05);(2)after treatment,the levels of oxygen partial pressure(PaO_(2)),carbon dioxide partial pressure(PaCO_(2)),blood oxygen saturation(SaO_(2))and hydrogen ion concentration index(pH)in the experimental group were significantly better than those in the control group,with statistical significance(P<0.05);(3)the levels of interleukin-6(IL-6),procalcitonin(PCT),C reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in experimental group were significantly lower than those in control group after treatment,with statistical significance(P<0.05);(4)there was no statistically significant difference in the total incidence of adverse reactions between the experimental group and the control group(P>0.05).Conclusion:For patients with neonatal respiratory distress syndrome,treatment with Caffeine Citrate Injection and Poractant Alfa Injection can improve arterial blood gas,reduce body inflammatory response,enhance therapeutic effect,and the combined administration does not increase the incidence of adverse reactions.

关 键 词：新生儿呼吸窘迫综合征 枸橼酸咖啡因注射液 猪肺磷脂注射液 

分 类 号：R722.1[医药卫生—儿科]