依托咪酯诱导全麻对MECT治疗精神分裂症患者血流动力学指标及应激反应的影响  

The Effect of Etomidate Induced General Anesthesia for MECT on Hemodynamic Indicators and Stress Response in Patients with Schizophrenia/

作　　者：张荣洪 陶婷 ZHANG Ronghong;TAO Ting(Department of Anesthesiology,the Third People's Hospital of Ganzhou,Ganzhou 341000,China;不详)

机构地区：[1]赣州市第三人民医院麻醉科,江西赣州341000 [2]宜春市第二人民医院麻醉科,江西宜春336000

出　　处：《中国医学创新》2024年第10期109-112,共4页Medical Innovation of China

摘　　要：目的:观察依托咪酯诱导全麻无抽搐电休克疗法(MECT)对精神分裂症(SP)患者血流动力学指标及应激反应的影响。方法:按照随机数字表法将2022年5月—2023年5月赣州市第三人民医院收治的86例SP患者分为两组,各43例。两组均进行MECT治疗,对照组采用丙泊酚诱导全麻,观察组采用依托咪酯诱导全麻。比较两组不同时点血流动力学指标、应激反应、不良反应情况。结果:对照组麻醉后5 min(T_(1))收缩压、心率均低于麻醉前(T_(0)),T_(1)时舒张压高于T_(0)时,MECT时(T_(2))、MECT后5 min(T_(3))时收缩压、心率均高于T_(0)、T_(1)(P<0.05);观察组T_(1)时收缩压、心率均低于T_(0)时,T_(2)、T_(3)时收缩压及心率均高于T_(0)、T_(1)时(P<0.05);观察组T_(0)、T_(1)、T_(2)、T_(3)时舒张压比较,差异均无统计学意义(P>0.05)。观察组T_(2)、T_(3)收缩压、舒张压、心率均低于对照组(P<0.05),观察组T_(1)时收缩压、心率均高于对照组,舒张压低于对照组(P<0.05)。T_(3)时两组甲肾上腺(NE)、肾上腺素(E)水平、皮质醇(Cor)均提高,且观察组均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:依托咪酯诱导全麻利于稳定SP患者MECT治疗期间血流动力学指标,降低应激反应,保障治疗顺利完成,且具有较高安全性。Objective:To observe the effects of Etomidate induced general anesthesia for without modified electric convulsive therapy(MECT)on hemodynamic indicators and stress response in patients with schizophrenia(SP).Method:A total of 86 SP patients admitted to the Third People's Hospital of Ganzhou from May 2022 to May 2023 were divided into two groups using a random number table method,with 43 patients in each group.Both groups of patients underwent MECT treatment,with the control group receiving Propofol induced general anesthesia and the observation group receiving Etomidate induced general anesthesia.The hemodynamic indicators at different time points,stress reactions,and adverse reactions between the two groups were compared.Result:Systolic blood pressure and heart rate in the control group at 5 minutes after anesthesia(T_(1))were lower compared to before anesthesia(T_(0)),diastolic blood pressure at T_(1) was higher compared to T_(0),and systolic blood pressure and heart rate at MECT(T_(2))and 5 minutes after MECT(T_(3))were higher compared to T_(0) and T_(1)(P<0.05);the systolic blood pressure and heart rate of the observation group were lower at T_(1) than at T_(0),and the systolic blood pressure and heart rate at T_(2) and T_(3) were higher than those at T_(0) and T_(1)(P<0.05);comparison of diastolic blood pressure at T_(0),T_(1),T_(2),and T_(3) in the observation group,the differences were not statistically significant(P>0.05).The systolic blood pressure,diastolic blood pressure,and heart rate of the observation group at T_(2) and T_(3) were all lower than those of the control group(P<0.05),the systolic blood pressure,heart rate of the observation group T_(1) were all lower than those of the control group,diastolic blood pressure was lower than that of the control group(P<0.05).At T_(3),the levels of adrenal gland(NE),adrenaline(E),and cortisol(Cor)in both groups were increased,and those in the observation group were lower than those in the control group(P<0.05).There was no statistically significant differenc

关 键 词：精神分裂症 无抽搐电休克疗法 依托咪酯 血流动力学 应激反应 

分 类 号：R614[医药卫生—麻醉学]