TRPV1通道在感染性疾病中的研究进展  

Research progress of TRPV1 channel in infectious diseases

作　　者：赵博 李思维 邢甜 高萍 朱宏喆 李敏[2] Zhao Bo;Li Siwei;Xing Tian;Gao Ping;Zhu Hongzhe;Li Min(Department of Pharmacy,Northwest Women's and Children's Hospital,Xi'an 710061,Xhina;College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]西北妇女儿童医院药剂科,西安710061 [2]陕西中医药大学药学院,咸阳712046

出　　处：《国际医药卫生导报》2024年第7期1057-1062,共6页International Medicine and Health Guidance News

基　　金：国家自然科学基金(81303243);陕西省教育厅项目(20JC012);咸阳市科学技术研究与发展计划(S2023-ZDYF-SF-2249)。

摘　　要：瞬时感受器电位香草酸受体1(TRPV1)是瞬时感受电位家族成员中的一种非选择性阳离子通道,主要表达在感觉神经元上。TRPV1在体内分布广泛,生物作用复杂。近年来,研究发现通过激活或抑制TRPV1可以调控炎性因子、疼痛信号传导、体温和神经元敏感性等,参与感染性疾病的产生,但目前还未用于临床。本文参阅国内外相关文献,以TRPV1为靶点,对TRPV1在感染性疾病中的生理作用及其调控机制的研究进展作一综述,为感染性疾病的防治提供新思路。Transient receptor potential vanilloid receptor 1(TRPV1)is a non-selective cation channel in the members of the transient receptor potential family,and expresses mainly on sensory neurons.The receptor is widely distributed in vivo and has complex biological effects.In recent years,studies have found that inflammatory factors,pain signaling,body temperature,and neuronal sensitivity can be modulated by activating or inhibiting TRPV1,which may be involved in the production of infectious diseases,but it has not been used clinically.This paper reviews the physiological role of TRPV1 in infectious diseases and its regulatory mechanism,and provides new ideas for the prevention and treatment of infectious diseases.

关 键 词：感染性疾病 瞬时感受器电位香草酸受体1 调控机制 进展 

分 类 号：R51[医药卫生—内科学]